UCSF

ZINC03645145

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
November 9th, 2004 9 Yes

Popular Name: L-Leucine L-Leucine

Find On: PubMed — Wikipedia — Google

CAS Numbers: 20859-02-3 , 2508-63-6 , 259225-40-6 , 328-38-1 , 328-39-2 , 61-90-5 , 6322-53-8 , 7005-03-0 , 7517-19-3 / '6322-53-8 / '5845-53-4 , 78333-15-0 , 96084-09-2 , [328-38-1] , [328-39-2] , [61-90-5] , [7517-19-3]

Other Names:

"DL-Leucine, 98%"

"L-Leucine, 99%"

(+-)-Leucine; (RS)-Leucine; 2-amino-4-methylpentanoic acid; DL-Leucine; Hleu; L; Leu; Leucin; Leuzin

(+/-)-2-Amino-4-methylpentanoic acid

(2S)-2-Amino-4-methylpentanoate; (2S)-2-Amino-4-methylpentanoic acid; (S)-(+)-Leucine; (S)-2-Amino-4-methylpentanoate; (S)-2-Amino-4-methylpentanoic acid; (S)-2-Amino-4-methylvalerate; (S)-2-Amino-4-methylvaleric acid; (S)-Leucine; 4-methyl-L-Norvaline; L

(2S)-2-Amino-4-methylpentanoate;(2S)-2-Amino-4-methylpentanoic acid;(S)-(+)-Leucine;(S)-2-Amino-4-methylpentanoate;(S)-2-Amino-4-methylpentanoic acid;(S)-2-Amino-4-methylvalerate;(S)-2-Amino-4-methylvaleric acid;(S)-Leucine;4-Methyl-L-Norvaline;L-(+)-Leuc

(2S)-2-amino-4-methylpentanoic acid

(2S)-2-amino-4-methylpentanoic acid; (S)-(+)-leucine; (S)-leucine; L-Leucin; L-Leuzin

(2S)-alpha-2-Amino-4-methylvaleric acid; (2S)-alpha-Leucine; (S)-2-Amino-4-methylpentanoic acid; (S)-2-Amino-4-methylvaleric acid; (S)-Leucine; 2-Amino-4-methylpentanoic acid (L); 2-Amino-4-methylpentanoic acid, (S)-; 2-Amino-4-methylvaleric acid; 2-Amino

(2S)-alpha-2-Amino-4-methylvaleric acid; (2S)-alpha-Leucine; 2-Amino-4-methylvaleric acid; 61-90-5; C00123; L-Leucine

(2S)-alpha-2-amino-4-methylvaleric acid; (2S)-alpha-leucine; 2-amino-4-methylvaleric acid; 61-90-5; L-leucine; leu; leucine

(R-)-2-Amino-4-methylvaleric acid

(S)-(+)-Leucine

(S)-2-Amino-4-methyl-pentanoic acid methyl ester hydrochloride

(S)-2-Amino-4-methylpentanoic acid

(S)-2-Amino-4-methylpentanoic acid; (S)-2-Amino-4-methylvaleric acid; (S)-Leucine; 2-Amino-4-methylpentanoic acid (L); 2-Amino-4-methylpentanoic acid, (S)-; 2-Amino-4-methylvaleric acid (L); AI3-08899; EINECS 200-522-0; FEMA No. 3297; L-(-)-2-Amino-4-meth

(S)-2-Amino-4-methylvaleric acid

(S)-Leucine

1-Leucine

2-amino-4-methylpentanoic acid

2-Amino-4-methylpentanoic acid hydrochloride

2-Amino-4-methylvaleric acid

61-90-5; D00030; L-Leucine (JP16); Leucine (USP)

61-90-5; leucine; nsc46709

751

alpha-Amino-gamma-methylvaleric acid

ALPHA-AMINO-ISO-CAPROIC ACID

alpha-Aminoisocaproic acid

C16439; Leucine

CHEBI:10866; CHEBI:43695; CHEBI:43733; CHEBI:43646; CHEBI:43814; CHEBI:21348; CHEBI:13131; CHEBI:6260

D-2-Amino-4-methylpentanoic acid

D-Leucine

D-Leucine methyl ester hydrochloride

D-Leucine methyl ester hydrochloride, 98%+

DL-2-Amino-4-methylpentanoic acid

DL-Leucine

DL-Leucine, 99%

DL-LEUCINE-4,5,5,5,6,6,6-D7

H-DL-Leu-OH

H-Leu-OH

L-(+)-Leucine

L-(-)-2-Amino-4-methylpentanoic acid

L-a-Aminoisocaproic acid

L-Leucine (JAN); Leucine (INN

L-leucine zwitterion

L-Leucine [61-90-5]

L-Leucine, 99%

L-leucine-[3,4,5-3h(n)]

L-leucine; leucine zwitterion

L-LEUCINE; [61-90-5]

Leu

Leucin

Leucine

LEUCINE DL-

Leucine, l-[3,4,5-3h(n)]-

MFCD00002617

MFCD00063087

MFCD00067541

MFCD00083396

MFCD00083399

MFCD23140984

USAN

USP)

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -1.38 2.28 -37.79 3 3 0 68 131.175 3 ↓

Vendor Notes

Note Type Comments Provided By
Molecular_Solubility 1.034 Bitter DB
SOLUBILITY 1 M HCl: 50 mg/mL Indofine
UniProt Database Links 104K_THEAN; 194K_TRVSY; 2ABB_RAT; 2ENR_CLOTY; 404L_IIV6; 4F2_HUMAN; 4F2_MOUSE; 4F2_RABIT; 4F2_RAT; 7LESS_DROME; A145_VACCC; A145_VACCW; A145_VAR67; A2GL_HUMAN; A60DA_DROME; AAC1_DICDI; AAM_RHOER; AAP6_ARATH; AAR2_YEAST; AB13C_ARATH; AB140_YEAST; ABAA_EMEN ChEBI
Mp [°C] 286 - 288 Acros Organics
MP 293 - 296 Enamine Building Blocks
MP 293...296 Enamine Building Blocks
UniProt Database Links 4F2_HUMAN; 4F2_MOUSE; 4F2_RABIT; 4F2_RAT; CDLS_BACLD; CDLS_BACSU; CDLS_CORJK; CDLS_PHOLL; CDLS_STAHJ; CDTS_MYCTU; CLPS_STRNR; COGS_HYPLI; DAPDH_CORGL; DAPDH_LYSSH; DAPDH_URETH; DHLE_BACCE; DHLE_BACCR; DHLE_BACLI; DHLE_BACSU; DHLE_GEOSE; DHLE_THEIN; GELE_E ChEBI
ALOGPS_SOLUBILITY 6.98e+01 g/l DrugBank-nutriceuticals
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Purity 95% Fluorochem
Purity 95+% Matrix Scientific
Purity 98% Fluorochem
M.P >300 °C Indofine
Melting_Point >300? Alfa-Aesar
Melting_Point >300° Alfa-Aesar
Melting_Point ca 294? subl. Alfa-Aesar
Melting_Point ca 294° subl. Alfa-Aesar
Patent Database Links EP0803576; EP0928790; EP1123935; EP1127869; EP1422218; EP1568283; EP1582208; EP1609462; EP1616963; EP1627884; EP1632233; EP1656931; EP1762232; EP1774858; EP1820497; EP1849466; EP1869977; EP1870419; EP1875921; EP1935417; EP1983044; GB1212533; GB1320104; US ChEBI
Patent Database Links EP0898963; EP0922699; EP0933365; EP1113008; EP1123929; EP1132380; EP1219634; EP1336604; EP1338588; EP1348759; EP1364941; EP1422218; EP1496116; EP1512696; EP1527782; EP1536009; EP1541140; EP1541141; EP1550720; EP1552826; EP1557173; EP1557466; EP1557469; EP ChEBI
Warnings IRRITANT Matrix Scientific
Notes Ph.Eur, Pyrogen free Apollo Scientific Bioactives
Reactome Database Links REACT_111140; REACT_111222; REACT_1136; REACT_13449; REACT_13479; REACT_13482; REACT_13593; REACT_13642; REACT_13741; REACT_14802; REACT_14843; REACT_15318; REACT_15357; REACT_15441; REACT_15504; REACT_15542; REACT_19313; REACT_19377; REACT_2034; REACT_21 ChEBI
S phrase S24/25: Avoid contact with skin and eyes. Acros Organics

Activity (Go SEA)

Direct Reactome Annotations (via ChEBI)

Description Species
Amino acid transport across the plasma membrane
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing: Ubiquitination & Proteasome degradation
Branched-chain amino acid catabolism
Cross-presentation of soluble exogenous antigens (endosomes)
Cytosolic tRNA aminoacylation
Endosomal/Vacuolar pathway
ER-Phagosome pathway
Glutathione synthesis and recycling
Mitochondrial tRNA aminoacylation
Na+/Cl- dependent neurotransmitter transporters
Proton/oligonucleotide cotransporters

Analogs ( Draw Identity 99% 90% 80% 70% )