| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 26th, 2005 | 23 | Yes |
Popular Name: Norfloxacin Norfloxacin
Find On: PubMed — Wikipedia — Google
CAS Numbers: 118803-81-9 , 70458-96-7
1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[1-piperazinyl]-3-quinoline- carboxylic acid
1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
118803-81-9; D08287; Norfloxacin nicotinate; Quinabic soluble powder (TN) [veterinary]
3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-
3-quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
70458-96-7; C06687; Norfloxacin
70458-96-7; D00210; NFLX; Norfloxacin (JP16/USP/INN); Noroxin (TN)
70458-96-7; Norfloxacin; Prestwick_633
Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin
Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin, Norfloxacin
ETHYLFLUOROOXOPIPERAZINYLDIHYDROQUINOLINECARBOXYLICACI
Norfloxacin [USAN:BAN:INN:JAN]
Norfloxacin, 98%, analytical standard
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.69 | 8.56 | -108.13 | 2 | 6 | 0 | 82 | 319.336 | 3 | ↓ |
| Hi High (pH 8-9.5) | -0.69 | 7.25 | -65.36 | 1 | 6 | -1 | 77 | 318.328 | 3 | ↓ |
| Mid Mid (pH 6-8) | -3.43 | 6.54 | -88.24 | 3 | 6 | 1 | 85 | 320.344 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.01e+00 g/l | DrugBank-approved |
| MP | 221 | TCI |
| Purity | 95% | Fluorochem |
| Purity | >99% | APIChem |
| Therapy | antibacterial | SMDC Iconix |
| biological_use | Antibacterial agent | IBScreen Bioactives |
| Indications | antibiotic | KeyOrganics Bioactives |
| UniProt Database Links | CSDA_ECOLI; FLQE1_MYCTU; FLQE2_MYCTU; FLQE3_MYCTU; HMRM_HAEIN; MDTH_ECO24; MDTH_ECO27; MDTH_ECO45; MDTH_ECO55; MDTH_ECO57; MDTH_ECO5E; MDTH_ECO7I; MDTH_ECO81; MDTH_ECO8A; MDTH_ECOBW; MDTH_ECODH; MDTH_ECOHS; MDTH_ECOK1; MDTH_ECOL5; MDTH_ECOL6; MDTH_ECOLC | ChEBI |
| mechanism | Inhibitor of the A subunit of bacterial DNA gyrase, an enzyme which is essential for DNA replication | IBScreen Bioactives |
| Warnings | IRRITANT | Matrix Scientific |
| Target | Others | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GYRA-1-B | DNA Gyrase Subunit A (cluster #1 Of 1), Bacterial | Bacteria | 600 | 0.38 | Binding ≤ 10μM |
| GYRB-1-B | DNA Gyrase Subunit B (cluster #1 Of 1), Bacterial | Bacteria | 600 | 0.38 | Binding ≤ 10μM |
| PARC-1-B | Topoisomerase IV Subunit A (cluster #1 Of 1), Bacterial | Bacteria | 3500 | 0.33 | Binding ≤ 10μM |
| Z104301-1-O | GABA-A Receptor; Anion Channel (cluster #1 Of 8), Other | Other | 20 | 0.47 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GYRA_ECOLI | P0AES4 | DNA Gyrase Subunit A, Ecoli | 600 | 0.38 | Binding ≤ 1μM |
| GYRB_ECOLI | P0AES6 | DNA Gyrase Subunit B, Ecoli | 600 | 0.38 | Binding ≤ 1μM |
| Z104301 | Z104301 | GABA-A Receptor; Anion Channel | 20 | 0.47 | Binding ≤ 1μM |
| GYRA_ECOLI | P0AES4 | DNA Gyrase Subunit A, Ecoli | 600 | 0.38 | Binding ≤ 10μM |
| GYRB_ECOLI | P0AES6 | DNA Gyrase Subunit B, Ecoli | 600 | 0.38 | Binding ≤ 10μM |
| Z104301 | Z104301 | GABA-A Receptor; Anion Channel | 20 | 0.47 | Binding ≤ 10μM |
| PARC_STAAU | P0C1U9 | Topoisomerase IV Subunit A, Staau | 3500 | 0.33 | Binding ≤ 10μM |
