Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.10	9.05	-56.28	5	9	1	115	439.569	7	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.10	7.78	-16.81	4	9	0	111	438.561	7	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AURKA-1-E	Serine/threonine-protein Kinase Aurora-A (cluster #1 Of 3), Eukaryotic	Eukaryotes	4	0.38	Binding ≤ 10μM
AURKB-1-E	Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic	Eukaryotes	18	0.35	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
AURKA_HUMAN	O14965	Serine/threonine-protein Kinase Aurora-A, Human	3.7	0.38	Binding ≤ 1μM
AURKB_HUMAN	Q96GD4	Serine/threonine-protein Kinase Aurora-B, Human	18	0.35	Binding ≤ 1μM
AURKA_HUMAN	O14965	Serine/threonine-protein Kinase Aurora-A, Human	3.7	0.38	Binding ≤ 10μM
AURKB_HUMAN	Q96GD4	Serine/threonine-protein Kinase Aurora-B, Human	18	0.35	Binding ≤ 10μM

Description	Species
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins	Homo sapiens (AURKA_HUMAN)
Mitotic Prometaphase	Homo sapiens (AURKB_HUMAN)
Regulation of PLK1 Activity at G2/M Transition	Homo sapiens (AURKA_HUMAN)
Resolution of Sister Chromatid Cohesion	Homo sapiens (AURKB_HUMAN)
Separation of Sister Chromatids	Homo sapiens (AURKB_HUMAN)