| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 5th, 2010 | 36 | Yes |
Popular Name: N/A N/A
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1025720-94-8 , 1196681-44-3 , [1025720-94-8] , [1196681-44-3]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.28 | 9.55 | -18.35 | 3 | 8 | 0 | 108 | 512.9 | 7 | ↓ |
| Ref Reference (pH 7) | 3.08 | 8.8 | -49.02 | 2 | 8 | -1 | 111 | 511.892 | 7 | ↓ |
| Mid Mid (pH 6-8) | 4.34 | 8.9 | -18.53 | 3 | 8 | 0 | 112 | 512.9 | 7 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Target | c-Met | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AURKB-1-E | Serine/threonine-protein Kinase Aurora-B (cluster #1 Of 2), Eukaryotic | Eukaryotes | 78 | 0.28 | Binding ≤ 10μM |
| FLT3-1-E | Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 16 | 0.30 | Binding ≤ 10μM |
| LCK-1-E | Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic | Eukaryotes | 120 | 0.27 | Binding ≤ 10μM |
| MERTK-1-E | Proto-oncogene Tyrosine-protein Kinase MER (cluster #1 Of 1), Eukaryotic | Eukaryotes | 14 | 0.31 | Binding ≤ 10μM |
| MET-1-E | Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4 | 0.33 | Binding ≤ 10μM |
| NTRK1-1-E | Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 290 | 0.25 | Binding ≤ 10μM |
| NTRK2-1-E | Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 190 | 0.26 | Binding ≤ 10μM |
| RON-1-E | Macrophage-stimulating Protein Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.34 | Binding ≤ 10μM |
| TYRO3-1-E | Tyrosine-protein Kinase Receptor TYRO3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4 | 0.33 | Binding ≤ 10μM |
| UFO-1-E | Tyrosine-protein Kinase Receptor UFO (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1 | 0.35 | Binding ≤ 10μM |
| VGFR2-1-E | Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 180 | 0.26 | Binding ≤ 10μM |
| Z103342-1-O | NCI-H1993 (cluster #1 Of 1), Other | Other | 150 | 0.27 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MET_HUMAN | P08581 | Hepatocyte Growth Factor Receptor, Human | 20 | 0.30 | Binding ≤ 1μM |
| RON_HUMAN | Q04912 | Macrophage-stimulating Protein Receptor, Human | 1.8 | 0.34 | Binding ≤ 1μM |
| NTRK1_HUMAN | P04629 | Nerve Growth Factor Receptor Trk-A, Human | 290 | 0.25 | Binding ≤ 1μM |
| NTRK2_HUMAN | Q16620 | Neurotrophic Tyrosine Kinase Receptor Type 2, Human | 190 | 0.26 | Binding ≤ 1μM |
| MERTK_HUMAN | Q12866 | Proto-oncogene Tyrosine-protein Kinase MER, Human | 14 | 0.31 | Binding ≤ 1μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 78 | 0.28 | Binding ≤ 1μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 120 | 0.27 | Binding ≤ 1μM |
| FLT3_HUMAN | P36888 | Tyrosine-protein Kinase Receptor FLT3, Human | 16 | 0.30 | Binding ≤ 1μM |
| TYRO3_HUMAN | Q06418 | Tyrosine-protein Kinase Receptor TYRO3, Human | 4.3 | 0.33 | Binding ≤ 1μM |
| UFO_HUMAN | P30530 | Tyrosine-protein Kinase Receptor UFO, Human | 1.1 | 0.35 | Binding ≤ 1μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 180 | 0.26 | Binding ≤ 1μM |
| MET_HUMAN | P08581 | Hepatocyte Growth Factor Receptor, Human | 20 | 0.30 | Binding ≤ 10μM |
| RON_HUMAN | Q04912 | Macrophage-stimulating Protein Receptor, Human | 1.8 | 0.34 | Binding ≤ 10μM |
| NTRK1_HUMAN | P04629 | Nerve Growth Factor Receptor Trk-A, Human | 290 | 0.25 | Binding ≤ 10μM |
| NTRK2_HUMAN | Q16620 | Neurotrophic Tyrosine Kinase Receptor Type 2, Human | 190 | 0.26 | Binding ≤ 10μM |
| MERTK_HUMAN | Q12866 | Proto-oncogene Tyrosine-protein Kinase MER, Human | 14 | 0.31 | Binding ≤ 10μM |
| AURKB_HUMAN | Q96GD4 | Serine/threonine-protein Kinase Aurora-B, Human | 78 | 0.28 | Binding ≤ 10μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 120 | 0.27 | Binding ≤ 10μM |
| FLT3_HUMAN | P36888 | Tyrosine-protein Kinase Receptor FLT3, Human | 16 | 0.30 | Binding ≤ 10μM |
| TYRO3_HUMAN | Q06418 | Tyrosine-protein Kinase Receptor TYRO3, Human | 4.3 | 0.33 | Binding ≤ 10μM |
| UFO_HUMAN | P30530 | Tyrosine-protein Kinase Receptor UFO, Human | 1.1 | 0.35 | Binding ≤ 10μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 180 | 0.26 | Binding ≤ 10μM |
| Z103342 | Z103342 | NCI-H1993 | 150 | 0.27 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins | |
| ARMS-mediated activation | |
| CD28 co-stimulation | |
| CD28 dependent PI3K/Akt signaling | |
| CD28 dependent Vav1 pathway | |
| Cell surface interactions at the vascular wall | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CTLA4 inhibitory signaling | |
| DAP12 signaling | |
| Downstream TCR signaling | |
| EPHA-mediated growth cone collapse | |
| Frs2-mediated activation | |
| Generation of second messenger molecules | |
| GPVI-mediated activation cascade | |
| Integrin cell surface interactions | |
| Interleukin-2 signaling | |
| Mitotic Prometaphase | |
| Nef and signal transduction | |
| Nef Mediated CD4 Down-regulation | |
| Neurophilin interactions with VEGF and VEGFR | |
| NGF-independant TRKA activation | |
| PD-1 signaling | |
| PECAM1 interactions | |
| Phosphorylation of CD3 and TCR zeta chains | |
| PI3K/AKT activation | |
| PIP3 activates AKT signaling | |
| PLC-gamma1 signalling | |
| Regulation of KIT signaling | |
| Resolution of Sister Chromatid Cohesion | |
| Retrograde neurotrophin signalling | |
| Sema4D mediated inhibition of cell attachment and migration | |
| Separation of Sister Chromatids | |
| Signaling by SCF-KIT | |
| Signalling to p38 via RIT and RIN | |
| Signalling to RAS | |
| Signalling to STAT3 | |
| Translocation of ZAP-70 to Immunological synapse | |
| TRKA activation by NGF | |
| VEGF binds to VEGFR leading to receptor dimerization | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
No pre-computed analogs available. Try a structural similarity search.