Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.73	10.35	-35.94	1	2	1	14	297.205	4	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.73	7.92	-3.42	0	2	0	12	296.197	4	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
5HT2A-2-E	Serotonin 2a (5-HT2a) Receptor (cluster #2 Of 3), Eukaryotic	Eukaryotes	144	0.50	Binding ≤ 10μM
KCNH2-5-E	HERG (cluster #5 Of 5), Eukaryotic	Eukaryotes	2120	0.42	Binding ≤ 10μM
SC6A2-2-E	Norepinephrine Transporter (cluster #2 Of 2), Eukaryotic	Eukaryotes	290	0.48	Binding ≤ 10μM
SC6A3-3-E	Dopamine Transporter (cluster #3 Of 3), Eukaryotic	Eukaryotes	140	0.51	Binding ≤ 10μM
SC6A4-3-E	Serotonin Transporter (cluster #3 Of 4), Eukaryotic	Eukaryotes	11	0.59	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
SC6A3_HUMAN	Q01959	Dopamine Transporter, Human	140	0.51	Binding ≤ 1μM
SC6A2_HUMAN	P23975	Norepinephrine Transporter, Human	290	0.48	Binding ≤ 1μM
5HT2A_HUMAN	P28223	Serotonin 2a (5-HT2a) Receptor, Human	144	0.50	Binding ≤ 1μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	0.35	0.70	Binding ≤ 1μM
SC6A3_HUMAN	Q01959	Dopamine Transporter, Human	140	0.51	Binding ≤ 10μM
KCNH2_HUMAN	Q12809	HERG, Human	2120	0.42	Binding ≤ 10μM
SC6A2_HUMAN	P23975	Norepinephrine Transporter, Human	290	0.48	Binding ≤ 10μM
5HT2A_HUMAN	P28223	Serotonin 2a (5-HT2a) Receptor, Human	144	0.50	Binding ≤ 10μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	0.35	0.70	Binding ≤ 10μM

Description	Species
Dopamine clearance from the synaptic cleft	Homo sapiens (SC6A3_HUMAN)
G alpha (q) signalling events	Homo sapiens (5HT2A_HUMAN)
Na+/Cl- dependent neurotransmitter transporters	Homo sapiens (SC6A2_HUMAN)
Serotonin receptors	Homo sapiens (5HT2A_HUMAN)
Voltage gated Potassium channels	Homo sapiens (KCNH2_HUMAN)