In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
April 14th, 2010 | 33 | Yes |
Popular Name: (3Z)-2-oxo-3-[phenyl-[4-(1-piperidylmethyl)anilino]methylene]indoline-6-carbonitrile (3Z)-2-oxo-3-[phenyl-[4-(1-piper…
None
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 5.11 | 13.5 | -41.93 | 3 | 5 | 1 | 73 | 435.551 | 5 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
VGFR2-1-E | Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 248 | 0.28 | Binding ≤ 10μM |
Z81057-1-O | HUVEC (Umbilical Vein Endothelial Cells) (cluster #1 Of 4), Other | Other | 281 | 0.28 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 248 | 0.28 | Binding ≤ 1μM |
VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 248 | 0.28 | Binding ≤ 10μM |
Z81057 | Z81057 | HUVEC (Umbilical Vein Endothelial Cells) | 281 | 0.28 | Functional ≤ 10μM |
Description | Species |
---|---|
EPHA-mediated growth cone collapse | |
Integrin cell surface interactions | |
Neurophilin interactions with VEGF and VEGFR | |
VEGF binds to VEGFR leading to receptor dimerization | |
VEGFA-VEGFR2 Pathway | |
VEGFR2 mediated cell proliferation |