| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 26th, 2005 | 13 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.33 | -2.82 | -74.86 | 3 | 5 | -1 | 107 | 184.171 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM1-3-E | Metabotropic Glutamate Receptor 1 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1600 | 0.62 | Binding ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 330 | 0.70 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2200 | 0.61 | Binding ≤ 10μM |
| GRM5-4-E | Metabotropic Glutamate Receptor 5 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 720 | 0.66 | Binding ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5300 | 0.57 | Binding ≤ 10μM |
| GRM1-4-E | Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 1600 | 0.62 | Functional ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 330 | 0.70 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2200 | 0.61 | Functional ≤ 10μM |
| GRM5-5-E | Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic | Eukaryotes | 720 | 0.66 | Functional ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5300 | 0.57 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 330 | 0.70 | Binding ≤ 1μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 720 | 0.66 | Binding ≤ 1μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 1600 | 0.62 | Binding ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 2200 | 0.61 | Binding ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 2200 | 0.61 | Binding ≤ 10μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 720 | 0.66 | Binding ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 5300 | 0.57 | Binding ≤ 10μM |
| GRM1_HUMAN | Q13255 | Metabotropic Glutamate Receptor 1, Human | 1600 | 0.62 | Functional ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 330 | 0.70 | Functional ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 2200 | 0.61 | Functional ≤ 10μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 720 | 0.66 | Functional ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 5300 | 0.57 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events |
