| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 22nd, 2008 | 13 | Yes |
Popular Name: (1S,3S,4S,5R)-3-aminobicyclo[2.1.1]hexane-3,5-dicarboxylic (1S,3S,4S,5R)-3-aminobicyclo[2.1…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.33 | 1.49 | -43.37 | 3 | 5 | -1 | 108 | 184.171 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM1-4-E | Metabotropic Glutamate Receptor 1 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 1600 | 0.62 | Functional ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 330 | 0.70 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 330 | 0.70 | Functional ≤ 10μM |
| GRM5-5-E | Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic | Eukaryotes | 1600 | 0.62 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM1_RAT | P23385 | Metabotropic Glutamate Receptor 1, Rat | 1600 | 0.62 | Functional ≤ 10μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 330 | 0.70 | Functional ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 330 | 0.70 | Functional ≤ 10μM |
| GRM5_RAT | P31424 | Metabotropic Glutamate Receptor 5, Rat | 1600 | 0.62 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events |
