Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.73	14.14	-59.43	4	9	1	115	590.72	12	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.73	12.71	-30.12	3	9	0	111	589.712	12	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
MC3R-1-E	Melanocortin Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	282	0.21	Binding ≤ 10μM
MC4R-1-E	Melanocortin Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	5	0.27	Binding ≤ 10μM
MSHR-1-E	Melanocortin Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	271	0.21	Binding ≤ 10μM
MC3R-1-E	Melanocortin Receptor 3 (cluster #1 Of 1), Eukaryotic	Eukaryotes	52	0.24	Functional ≤ 10μM
MC4R-1-E	Melanocortin Receptor 4 (cluster #1 Of 1), Eukaryotic	Eukaryotes	3	0.28	Functional ≤ 10μM
MSHR-1-E	Melanocortin Receptor 1 (cluster #1 Of 1), Eukaryotic	Eukaryotes	98	0.23	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
MSHR_HUMAN	Q01726	Melanocortin Receptor 1, Human	271	0.21	Binding ≤ 1μM
MC3R_HUMAN	P41968	Melanocortin Receptor 3, Human	282	0.21	Binding ≤ 1μM
MC4R_HUMAN	P32245	Melanocortin Receptor 4, Human	5	0.27	Binding ≤ 1μM
MSHR_HUMAN	Q01726	Melanocortin Receptor 1, Human	271	0.21	Binding ≤ 10μM
MC3R_HUMAN	P41968	Melanocortin Receptor 3, Human	282	0.21	Binding ≤ 10μM
MC4R_HUMAN	P32245	Melanocortin Receptor 4, Human	5	0.27	Binding ≤ 10μM
MSHR_HUMAN	Q01726	Melanocortin Receptor 1, Human	98	0.23	Functional ≤ 10μM
MC3R_HUMAN	P41968	Melanocortin Receptor 3, Human	52	0.24	Functional ≤ 10μM
MC4R_HUMAN	P32245	Melanocortin Receptor 4, Human	2.7	0.28	Functional ≤ 10μM