| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 28th, 2010 | 20 | Yes |
Popular Name: DNC009960 DNC009960
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.30 | 8.92 | -48.25 | 1 | 3 | -1 | 60 | 269.32 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MMP12-2-E | Macrophage Metalloelastase (cluster #2 Of 2), Eukaryotic | Eukaryotes | 790 | 0.43 | Binding ≤ 10μM |
| MMP13-4-E | Matrix Metalloproteinase 13 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 9990 | 0.35 | Binding ≤ 10μM |
| MMP2-2-E | 72 KDa Type IV Collagenase (cluster #2 Of 3), Eukaryotic | Eukaryotes | 4520 | 0.37 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MMP12_HUMAN | P39900 | Matrix Metalloproteinase 12, Human | 340 | 0.45 | Binding ≤ 1μM |
| MMP12_HUMAN | P39900 | Matrix Metalloproteinase 12, Human | 340 | 0.45 | Binding ≤ 10μM |
| MMP13_HUMAN | P45452 | Matrix Metalloproteinase 13, Human | 9990 | 0.35 | Binding ≤ 10μM |
| MMP2_HUMAN | P08253 | Matrix Metalloproteinase-2, Human | 4520 | 0.37 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Assembly of collagen fibrils and other multimeric structures | |
| Collagen degradation | |
| Degradation of the extracellular matrix | |
| EPH-ephrin mediated repulsion of cells | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l |
