UCSF

ZINC00537791

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
September 26th, 2005 34 No

Popular Name: Glimepiride Glimepiride

Find On: PubMed — Wikipedia — Google

CAS Numbers: 93479-97-1 , 1406-18-4; 93479-97-1 , 93479-97-1 , [93479-97-1]

Other Names:

1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea

1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; Glime

1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1H-Pyrrole-1-carboxamide, 2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-,

1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea

1H-Pyrrole-1-carboxamide, 2,5-dihydro-3-ethyl-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-

1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-(2-(4-(((((4-methylcyclohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo-, trans-

3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro

3-ethyl-4-methyl-N-(4-(N-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

3-Ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide

4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide

64598P

93479-97-1

93479-97-1; Amaryl (TN); D00593; Glimepiride (JP16/USP/INN)

93479-97-1; C07669; Glimepiride

AB00513874

AC-476

AC1L1G0T

Amarel

Amaryl

Amaryl (TN)

Amaryl, Glista OD

Amaryl, Glista OD, Glimepiride

AVANDARYL; GLIMEPIRIDE; LS-187966; ROSIGLITAZONE MALEATE

BAN

Bio-0049

BPBio1_000751

BRD-K34776109-001-03-4

BRD-K42693031-001-01-8

BRN 5365754

BSPBio_000681

C07669

C24H34N4O5S

CAS-93479-97-1

CCRIS 7083

CHEBI:5383

CHEMBL1481

CID3476

CPD000466368

CPD000466368; GLIMEPIRIDE

CPD000466368; GLIMEPIRIDE; SAM001246710

D00593

DAP000132

DB00222

Endial

FDA

G2295_SIGMA

gimepiride; glimepirida; glimepiride; glimepiridum

gli-

Glimepirid

Glimepirid;Glimepirida;Glimepiridum;Glimepride

Glimepirida

Glimepirida [Spanish]

Glimepiride (BAN

Glimepiride (FDA

Glimepiride (JAN/USP/INN)

Glimepiride (USP

Glimepiride [USAN:BAN:INN]

Glimepiridum

Glimepiridum [Latin]

Glimepride

Glimer

GLIPIZIDE

Glymepirid

Grimepiride

HMS1570C03

HMS2052L03

HMS2090K18

HOE 490

HOE-490

I06-0029

I06-2285

INN

LS-136752

MFCD00878417

MLS000759495

MLS001076674

MLS001401419

MolPort-003-847-587

MolPort-003-987-461

MolPort-005-941-721

NCGC00016960-01

NCGC00161404-01

NCGC00161404-02

NCGC00181757-01

Novo-glimepiride

Oprea1_382896

PMS-glimepiride

Prestwick0_000651

Prestwick1_000651

Prestwick2_000651

Prestwick3_000651

Ratio-glimepiride

Roname

S1344_Selleck

SAM001246710

Sandoz glimepiride

SMR000466368

Solosa

SPBio_002602

TL8005924

UNII-6KY687524K

USAN

USAN)

USP)

ZINC00537791

Download: MOL2 SDF SMILES Flexibase

Annotations

Vendors

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.44 5.49 -64.87 2 9 -1 131 489.618 8 ↓
Ref Reference (pH 7) 3.44 5.33 -22.95 3 9 0 128 490.626 8 ↓
Ref Reference (pH 7) 2.52 2.55 -24.11 3 9 0 132 490.626 9 ↓
Lo Low (pH 4.5-6) 3.81 7.43 -20.32 3 9 0 125 490.626 7 ↓

Vendor Notes

Note Type Comments Provided By
MP 212-215° Oakwood Chemical
ALOGPS_SOLUBILITY 3.84e-02 g/l DrugBank-approved
Purity 97% Fluorochem
mechanism Cyclooxygenase pathway inhibitor, IBScreen Bioactives
Target DPP-4 Selleck Chemicals
PUBCHEM_PATENT_ID EP0254626A2; EP0561564A3; EP0601001A1; EP0601001B1; EP0604853A2; EP0604853A3; EP0634166A1; EP0649660A2; EP0649660A3; EP0681833A3; EP0749751A2; EP0749751A3; EP0801949A1; EP0832065A1; EP0832066A1; EP0861666A3; EP0927028A1; EP0941077A1; EP0998291A1; EP100178 IBM Patent Data
Patent Database Links EP1088824; EP1136071; EP1258253; EP1354882; EP1391460; EP1452526; EP1452530; EP1479666; EP1493443; EP1533292; EP1553091; EP1559710; EP1595544; EP1669345; EP1671637; EP1700848; EP1741435; EP1743655; EP1785144; EP1792620; EP1813273; EP1829858; EP1832291; EP ChEBI
biological_use Hypoglycaemic agent IBScreen Bioactives
Therapy hypoglycemic, antidiabetic SMDC Iconix
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : Sequoia Research Products Ltd.; NCC_SUPPLIER_STRUCTURE_ID : SRP01525g NIH Clinical Collection via PubChem
mechanism Potassium channel blocker IBScreen Bioactives
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: Sequoia Research Products Ltd.; SUPPLIER_STRUCTURE_ID: SRP01525g NIH Clinical Collection via PubChem
Indications type II diabetes KeyOrganics Bioactives

Activity (Go SEA)

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.