Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.78	7.27	-54.75	3	6	1	73	434.512	2	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.78	5.47	-15.89	2	6	0	71	433.504	2	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	15	0.34	Binding ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	25	0.33	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	5	0.36	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	15	0.34	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	121	0.30	Binding ≤ 1μM
OPRK_CAVPO	P41144	Kappa Opioid Receptor, Guinea Pig	25	0.33	Binding ≤ 1μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	5.2	0.36	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	121	0.30	Binding ≤ 10μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	15	0.34	Binding ≤ 10μM
OPRK_CAVPO	P41144	Kappa Opioid Receptor, Guinea Pig	25	0.33	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	5.2	0.36	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN) Rattus norvegicus (OPRD_RAT)
G-protein activation	Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Rattus norvegicus (OPRD_RAT) Homo sapiens (OPRM_HUMAN)