| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| January 4th, 2006 | 22 | Yes |
Popular Name: DNC006905 DNC006905
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.18 | 2.94 | -9.07 | 0 | 4 | 0 | 36 | 300.354 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q862F3-1-E | Tubulin Alpha Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1300 | 0.37 | Binding ≤ 10μM |
| Q862L2-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1300 | 0.37 | Binding ≤ 10μM |
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 200 | 0.43 | Binding ≤ 10μM |
| TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1300 | 0.37 | Binding ≤ 10μM |
| Q862F3-1-E | Tubulin Alpha Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2200 | 0.36 | Functional ≤ 10μM |
| Q862L2-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2200 | 0.36 | Functional ≤ 10μM |
| TBA1A-1-E | Tubulin Alpha-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1300 | 0.37 | Functional ≤ 10μM |
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1500 | 0.37 | Functional ≤ 10μM |
| TBB2B-1-E | Tubulin Beta Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2200 | 0.36 | Functional ≤ 10μM |
| TBB3-3-E | Tubulin Beta-3 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1500 | 0.37 | Functional ≤ 10μM |
| TBB4A-3-E | Tubulin Beta-4 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1500 | 0.37 | Functional ≤ 10μM |
| TBB4B-3-E | Tubulin Beta-2 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1500 | 0.37 | Functional ≤ 10μM |
| TBB5-1-E | Tubulin Beta-5 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1500 | 0.37 | Functional ≤ 10μM |
| TBB8-3-E | Tubulin Beta-8 Chain (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1500 | 0.37 | Functional ≤ 10μM |
| Z50591-2-O | Bos Taurus (cluster #2 Of 2), Other | Other | 2500 | 0.36 | Functional ≤ 10μM |
| Z80166-1-O | HT-29 (Colon Adenocarcinoma Cells) (cluster #1 Of 12), Other | Other | 13 | 0.50 | Functional ≤ 10μM |
| Z80224-1-O | MCF7 (Breast Carcinoma Cells) (cluster #1 Of 14), Other | Other | 15 | 0.50 | Functional ≤ 10μM |
| Z80269-1-O | MKN-45 (Gastric Adenocarcinoma Cells) (cluster #1 Of 3), Other | Other | 17 | 0.49 | Functional ≤ 10μM |
| Z80928-6-O | HCT-116 (Colon Carcinoma Cells) (cluster #6 Of 9), Other | Other | 20 | 0.49 | Functional ≤ 10μM |
| Z81001-1-O | TSGH 9201 (Gastric Carcinoma Cells) (cluster #1 Of 1), Other | Other | 20 | 0.49 | Functional ≤ 10μM |
| Z81024-5-O | NCI-H460 (Non-small Cell Lung Carcinoma) (cluster #5 Of 8), Other | Other | 60 | 0.46 | Functional ≤ 10μM |
| Z81115-1-O | KB (Squamous Cell Carcinoma) (cluster #1 Of 6), Other | Other | 16 | 0.50 | Functional ≤ 10μM |
| Z81335-2-O | HCT-15 (Colon Adenocarcinoma Cells) (cluster #2 Of 5), Other | Other | 9 | 0.51 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 200 | 0.43 | Binding ≤ 1μM |
| Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 1300 | 0.37 | Binding ≤ 10μM |
| Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 1300 | 0.37 | Binding ≤ 10μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 1300 | 0.37 | Binding ≤ 10μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 200 | 0.43 | Binding ≤ 10μM |
| Z50591 | Z50591 | Bos Taurus | 2500 | 0.36 | Functional ≤ 10μM |
| Z80928 | Z80928 | HCT-116 (Colon Carcinoma Cells) | 20 | 0.49 | Functional ≤ 10μM |
| Z81335 | Z81335 | HCT-15 (Colon Adenocarcinoma Cells) | 8.7 | 0.51 | Functional ≤ 10μM |
| Z80166 | Z80166 | HT-29 (Colon Adenocarcinoma Cells) | 13 | 0.50 | Functional ≤ 10μM |
| Z81115 | Z81115 | KB (Squamous Cell Carcinoma) | 11.9 | 0.50 | Functional ≤ 10μM |
| Z80224 | Z80224 | MCF7 (Breast Carcinoma Cells) | 15 | 0.50 | Functional ≤ 10μM |
| Z80269 | Z80269 | MKN-45 (Gastric Adenocarcinoma Cells) | 16.6 | 0.50 | Functional ≤ 10μM |
| Z81024 | Z81024 | NCI-H460 (Non-small Cell Lung Carcinoma) | 18.8 | 0.49 | Functional ≤ 10μM |
| Z81001 | Z81001 | TSGH 9201 (Gastric Carcinoma Cells) | 19.9 | 0.49 | Functional ≤ 10μM |
| TBA1A_PIG | P02550 | Tubulin Alpha Chain, Pig | 1300 | 0.37 | Functional ≤ 10μM |
| Q862F3_BOVIN | Q862F3 | Tubulin Alpha Chain, Bovin | 2000 | 0.36 | Functional ≤ 10μM |
| Q862L2_BOVIN | Q862L2 | Tubulin Alpha-1 Chain, Bovin | 2200 | 0.36 | Functional ≤ 10μM |
| TBB2B_BOVIN | Q6B856 | Tubulin Beta Chain, Bovin | 2000 | 0.36 | Functional ≤ 10μM |
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 1500 | 0.37 | Functional ≤ 10μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 1500 | 0.37 | Functional ≤ 10μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 1500 | 0.37 | Functional ≤ 10μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 1500 | 0.37 | Functional ≤ 10μM |
| TBB5_HUMAN | P07437 | Tubulin Beta-5 Chain, Human | 1500 | 0.37 | Functional ≤ 10μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 1500 | 0.37 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
