| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 31st, 2006 | 26 | Yes |
Popular Name: 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic 2-[1-amino-1-carboxy-2-(9H-xanth…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.75 | -0.83 | -67.84 | 3 | 6 | -1 | 117 | 352.366 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3 | 0.46 | Binding ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4 | 0.45 | Binding ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 530 | 0.34 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.46 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4 | 0.45 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 530 | 0.34 | Binding ≤ 10μM |
| GRM2-2-E | Metabotropic Glutamate Receptor 2 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 50 | 0.39 | Functional ≤ 10μM |
| GRM2-2-E | Metabotropic Glutamate Receptor 2 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 200 | 0.36 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 16 | 0.42 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 100 | 0.38 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 3.72 | 0.45 | Binding ≤ 1μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 4.11 | 0.45 | Binding ≤ 1μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 3.72 | 0.45 | Binding ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 4.11 | 0.45 | Binding ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 200 | 0.36 | Functional ≤ 10μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 50.3 | 0.39 | Functional ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 100 | 0.38 | Functional ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 16 | 0.42 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events |
