| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 1st, 2012 | 38 | No |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.54 | 13.65 | -51.03 | 3 | 10 | 1 | 96 | 561.494 | 8 | ↓ |
| Ref Reference (pH 7) | 5.17 | 11.81 | -46.83 | 3 | 10 | 1 | 100 | 561.494 | 9 | ↓ |
| Mid Mid (pH 6-8) | 5.54 | 11.43 | -18.46 | 2 | 10 | 0 | 95 | 560.486 | 8 | ↓ |
| Mid Mid (pH 6-8) | 5.17 | 9.59 | -13.59 | 2 | 10 | 0 | 99 | 560.486 | 9 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Reactome Database Links | REACT_121067; REACT_121289; REACT_121373; REACT_121386 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ABL1-1-E | Tyrosine-protein Kinase ABL (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2300 | 0.21 | Binding ≤ 10μM |
| ALK-1-E | ALK Tyrosine Kinase Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3078 | 0.20 | Binding ≤ 10μM |
| BMX-1-E | Tyrosine-protein Kinase BMX (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3405 | 0.20 | Binding ≤ 10μM |
| EPHB1-1-E | Ephrin Type-B Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3039 | 0.20 | Binding ≤ 10μM |
| FGFR1-1-E | Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5 | 0.31 | Binding ≤ 10μM |
| FGFR2-1-E | Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5 | 0.31 | Binding ≤ 10μM |
| FGFR3-1-E | Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.32 | Binding ≤ 10μM |
| FGFR4-1-E | Fibroblast Growth Factor Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 60 | 0.27 | Binding ≤ 10μM |
| FLT3-1-E | Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3252 | 0.20 | Binding ≤ 10μM |
| FYN-1-E | Tyrosine-protein Kinase FYN (cluster #1 Of 5), Eukaryotic | Eukaryotes | 1900 | 0.21 | Binding ≤ 10μM |
| INSR-1-E | Insulin Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3371 | 0.20 | Binding ≤ 10μM |
| JAK2-1-E | Tyrosine-protein Kinase JAK2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2882 | 0.20 | Binding ≤ 10μM |
| KIT-1-E | Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 750 | 0.23 | Binding ≤ 10μM |
| KSYK-1-E | Tyrosine-protein Kinase SYK (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5358 | 0.19 | Binding ≤ 10μM |
| LCK-1-E | Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic | Eukaryotes | 2500 | 0.21 | Binding ≤ 10μM |
| LYN-1-E | Tyrosine-protein Kinase Lyn (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3019 | 0.20 | Binding ≤ 10μM |
| MET-1-E | Hepatocyte Growth Factor Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3011 | 0.20 | Binding ≤ 10μM |
| NTRK2-1-E | Neurotrophic Tyrosine Kinase Receptor Type 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3139 | 0.20 | Binding ≤ 10μM |
| PGFRA-1-E | Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2718 | 0.21 | Binding ≤ 10μM |
| RET-1-E | Tyrosine-protein Kinase Receptor RET (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3352 | 0.20 | Binding ≤ 10μM |
| RON-1-E | Macrophage-stimulating Protein Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2891 | 0.20 | Binding ≤ 10μM |
| ROS1-1-E | Proto-oncogene Tyrosine-protein Kinase ROS (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3263 | 0.20 | Binding ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2969 | 0.20 | Binding ≤ 10μM |
| TIE2-1-E | Tyrosine-protein Kinase TIE-2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2051 | 0.21 | Binding ≤ 10μM |
| TYK2-1-E | Tyrosine-protein Kinase TYK2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3303 | 0.20 | Binding ≤ 10μM |
| VGFR1-1-E | Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1510 | 0.21 | Binding ≤ 10μM |
| VGFR2-1-E | Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 938 | 0.22 | Binding ≤ 10μM |
| VGFR3-1-E | Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2072 | 0.21 | Binding ≤ 10μM |
| YES-1-E | Tyrosine-protein Kinase YES (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1100 | 0.22 | Binding ≤ 10μM |
| Z103410-1-O | SW780 (cluster #1 Of 1), Other | Other | 32 | 0.28 | Functional ≤ 10μM |
| Z80036-1-O | BaF3 (IL-3-dependent Pro-B-cells) (cluster #1 Of 3), Other | Other | 2 | 0.32 | Functional ≤ 10μM |
| Z80996-1-O | HT1197 (Bladder Carcinoma Cells) (cluster #1 Of 1), Other | Other | 1157 | 0.22 | Functional ≤ 10μM |
| Z80036-1-O | BaF3 (IL-3-dependent Pro-B-cells) (cluster #1 Of 1), Other | Other | 1857 | 0.21 | ADME/T ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 0.9 | 0.33 | Binding ≤ 1μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 1.4 | 0.33 | Binding ≤ 1μM |
| FGFR3_HUMAN | P22607 | Fibroblast Growth Factor Receptor 3, Human | 0.7 | 0.34 | Binding ≤ 1μM |
| FGFR4_HUMAN | P22455 | Fibroblast Growth Factor Receptor 4, Human | 168 | 0.25 | Binding ≤ 1μM |
| KIT_HUMAN | P10721 | Stem Cell Growth Factor Receptor, Human | 750 | 0.23 | Binding ≤ 1μM |
| LYN_HUMAN | P07948 | Tyrosine-protein Kinase Lyn, Human | 300 | 0.24 | Binding ≤ 1μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 180 | 0.25 | Binding ≤ 1μM |
| ALK_HUMAN | Q9UM73 | ALK Tyrosine Kinase Receptor, Human | 3078 | 0.20 | Binding ≤ 10μM |
| EPHB1_HUMAN | P54762 | Ephrin Type-B Receptor 1, Human | 3039 | 0.20 | Binding ≤ 10μM |
| FGFR1_HUMAN | P11362 | Fibroblast Growth Factor Receptor 1, Human | 0.9 | 0.33 | Binding ≤ 10μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 1.4 | 0.33 | Binding ≤ 10μM |
| FGFR3_HUMAN | P22607 | Fibroblast Growth Factor Receptor 3, Human | 0.7 | 0.34 | Binding ≤ 10μM |
| FGFR4_HUMAN | P22455 | Fibroblast Growth Factor Receptor 4, Human | 168 | 0.25 | Binding ≤ 10μM |
| MET_HUMAN | P08581 | Hepatocyte Growth Factor Receptor, Human | 3011 | 0.20 | Binding ≤ 10μM |
| INSR_HUMAN | P06213 | Insulin Receptor, Human | 3371 | 0.20 | Binding ≤ 10μM |
| RON_HUMAN | Q04912 | Macrophage-stimulating Protein Receptor, Human | 2891 | 0.20 | Binding ≤ 10μM |
| NTRK2_HUMAN | Q16620 | Neurotrophic Tyrosine Kinase Receptor Type 2, Human | 3139 | 0.20 | Binding ≤ 10μM |
| PGFRA_HUMAN | P16234 | Platelet-derived Growth Factor Receptor Alpha, Human | 2718 | 0.21 | Binding ≤ 10μM |
| ROS1_HUMAN | P08922 | Proto-oncogene Tyrosine-protein Kinase ROS, Human | 3263 | 0.20 | Binding ≤ 10μM |
| KIT_HUMAN | P10721 | Stem Cell Growth Factor Receptor, Human | 2501 | 0.21 | Binding ≤ 10μM |
| ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 2300 | 0.21 | Binding ≤ 10μM |
| BMX_HUMAN | P51813 | Tyrosine-protein Kinase BMX, Human | 3405 | 0.20 | Binding ≤ 10μM |
| FYN_HUMAN | P06241 | Tyrosine-protein Kinase FYN, Human | 1900 | 0.21 | Binding ≤ 10μM |
| JAK2_HUMAN | O60674 | Tyrosine-protein Kinase JAK2, Human | 2882 | 0.20 | Binding ≤ 10μM |
| LCK_HUMAN | P06239 | Tyrosine-protein Kinase LCK, Human | 2500 | 0.21 | Binding ≤ 10μM |
| LYN_HUMAN | P07948 | Tyrosine-protein Kinase Lyn, Human | 300 | 0.24 | Binding ≤ 10μM |
| FLT3_HUMAN | P36888 | Tyrosine-protein Kinase Receptor FLT3, Human | 3252 | 0.20 | Binding ≤ 10μM |
| RET_HUMAN | P07949 | Tyrosine-protein Kinase Receptor RET, Human | 3352 | 0.20 | Binding ≤ 10μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 2969 | 0.20 | Binding ≤ 10μM |
| KSYK_HUMAN | P43405 | Tyrosine-protein Kinase SYK, Human | 5358 | 0.19 | Binding ≤ 10μM |
| TIE2_HUMAN | Q02763 | Tyrosine-protein Kinase TIE-2, Human | 2051 | 0.21 | Binding ≤ 10μM |
| TYK2_HUMAN | P29597 | Tyrosine-protein Kinase TYK2, Human | 3303 | 0.20 | Binding ≤ 10μM |
| YES_HUMAN | P07947 | Tyrosine-protein Kinase YES, Human | 1100 | 0.22 | Binding ≤ 10μM |
| VGFR1_HUMAN | P17948 | Vascular Endothelial Growth Factor Receptor 1, Human | 1510 | 0.21 | Binding ≤ 10μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 1449 | 0.22 | Binding ≤ 10μM |
| VGFR3_HUMAN | P35916 | Vascular Endothelial Growth Factor Receptor 3, Human | 2072 | 0.21 | Binding ≤ 10μM |
| Z80036 | Z80036 | BaF3 (IL-3-dependent Pro-B-cells) | 2 | 0.32 | Functional ≤ 10μM |
| Z80996 | Z80996 | HT1197 (Bladder Carcinoma Cells) | 1157 | 0.22 | Functional ≤ 10μM |
| Z103410 | Z103410 | SW780 | 32 | 0.28 | Functional ≤ 10μM |
| Z80036 | Z80036 | BaF3 (IL-3-dependent Pro-B-cells) | 1857 | 0.21 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| Signaling by FGFR1 amplification mutants | |
| Signaling by FGFR2 amplification mutants | |
| Signaling by FGFR3 mutants |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| Apoptotic cleavage of cellular proteins | |
| betaKlotho-mediated ligand binding | |
| CD28 co-stimulation | |
| CD28 dependent PI3K/Akt signaling | |
| CD28 dependent Vav1 pathway | |
| CDO in myogenesis | |
| Cell surface interactions at the vascular wall | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CRMPs in Sema3A signaling | |
| CTLA4 inhibitory signaling | |
| DAP12 signaling | |
| DCC mediated attractive signaling | |
| Downstream signal transduction | |
| Downstream TCR signaling | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| Factors involved in megakaryocyte development and platelet production | |
| Fc epsilon receptor (FCERI) signaling | |
| FCERI mediated Ca+2 mobilization | |
| FCERI mediated MAPK activation | |
| FCERI mediated NF-kB activation | |
| FCGR activation | |
| FGFR4 ligand binding and activation | |
| FRS2-mediated cascade | |
| Generation of second messenger molecules | |
| GPVI-mediated activation cascade | |
| Growth hormone receptor signaling | |
| Insulin receptor recycling | |
| Integrin alphaIIb beta3 signaling | |
| Integrin cell surface interactions | |
| Interferon alpha/beta signaling | |
| Interferon gamma signaling | |
| Interleukin receptor SHC signaling | |
| Interleukin-2 signaling | |
| Interleukin-3, 5 and GM-CSF signaling | |
| Interleukin-6 signaling | |
| IRS activation | |
| NCAM signaling for neurite out-growth | |
| Nef and signal transduction | |
| Nef Mediated CD4 Down-regulation | |
| Negative regulation of FGFR signaling | |
| Nephrin interactions | |
| Netrin mediated repulsion signals | |
| Neurophilin interactions with VEGF and VEGFR | |
| NGF-independant TRKA activation | |
| PD-1 signaling | |
| PECAM1 interactions | |
| Phospholipase C-mediated cascade | |
| Phosphorylation of CD3 and TCR zeta chains | |
| PI-3K cascade | |
| PI3K Cascade | |
| PIP3 activates AKT signaling | |
| Platelet Adhesion to exposed collagen | |
| Prolactin receptor signaling | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Regulation of IFNA signaling | |
| Regulation of IFNG signaling | |
| Regulation of KIT signaling | |
| Regulation of signaling by CBL | |
| RMTs methylate histone arginines | |
| Role of Abl in Robo-Slit signaling | |
| Role of LAT2/NTAL/LAB on calcium mobilization | |
| Role of phospholipids in phagocytosis | |
| Sema3A PAK dependent Axon repulsion | |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | |
| Sema4D mediated inhibition of cell attachment and migration | |
| SHC activation | |
| SHC-mediated cascade | |
| Signal attenuation | |
| Signaling by activated point mutants of FGFR1 | |
| Signaling by activated point mutants of FGFR3 | |
| Signaling by ERBB2 | |
| Signaling by FGFR mutants | |
| Signaling by FGFR2 amplification mutants | |
| Signaling by FGFR3 mutants | |
| Signaling by FGFR4 mutants | |
| Signaling by Insulin receptor | |
| Signaling by Leptin | |
| Signaling by PDGF | |
| Signaling by SCF-KIT | |
| t(4;14) translocations of FGFR3 | |
| Tie2 Signaling | |
| Translocation of ZAP-70 to Immunological synapse | |
| VEGF binds to VEGFR leading to receptor dimerization | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
No pre-computed analogs available. Try a structural similarity search.