| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 3rd, 2005 | 7 | Yes |
Popular Name: D-Serine D-Serine
Find On: PubMed — Wikipedia — Google
CAS Numbers: , 16428-75-4 , 204191-40-2 , 2899-36-7 , 302-84-1 , 312-84-5 , 56-45-1 , 6898-95-9 , N/A , [2899-36-7] , [312-84-5]
(+/-)-2-Amino-3-hydroxypropionic acid
(2R)-2-amino-3-hydroxypropanoate; D-serine anion
(2R)-2-amino-3-hydroxypropanoic acid; (R)-2-amino-3-hydroxypropanoic acid; D-Serin
(R)-2-Amino-3-hydroxypropionic acid
(S)-2-(Boc-amino)-3-hydroxypropionic acid hydrate
(S)-2-Amino-3-hydroxypropanoicacidhydrochloride
2-Amino-3-hydoxypropanoic acid
2-Amino-3-hydroxypropanoic acid
AI3-18476; D-Serine; EINECS 206-229-4; LS-144974; NSC 77689; Serine D-form
CHEBI:143888; CHEBI:42262; CHEBI:4245; CHEBI:21090; CHEBI:13019
DL-Serine methyl ester hydrochloride
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -3.67 | -3.05 | -33.75 | 4 | 4 | 0 | 88 | 105.093 | 2 | ↓ |
| Hi High (pH 8-9.5) | -3.67 | -3.44 | -40.48 | 3 | 4 | -1 | 86 | 104.085 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| MP | 215-225° | Oakwood Chemical |
| Melting_Point | 218-220? dec. | Alfa-Aesar |
| Melting_Point | 218-220° dec. | Alfa-Aesar |
| Mp [°C] | 220 | Acros Organics |
| MP | 220 °C | Indofine |
| MP | 238 - 240 | Enamine Building Blocks |
| MP | 238...240 | Enamine Building Blocks |
| Mp [°C] | 240 | Acros Organics |
| MP | 240°(dec.) | Oakwood Chemical |
| ALOGPS_SOLUBILITY | 4.80e+02 g/l | DrugBank-experimental |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Purity | 95% | Fluorochem |
| Purity | 98% | Fluorochem |
| Purity | 99% | APIChem |
| UniProt Database Links | AAA1_HUMAN; AAA1_MOUSE; AAA1_RAT; CYCA_ECO57; CYCA_ECOLI; DAPDH_URETH; DSD1_SCHPO; DSD1_YEAST; DSDC_ECOLI; DSDX_ECOLI; DTA_ARTSP; DTHAD_DELSH; HPA3_YEAST; OCP3_CALMC; OXDA_CAVPO; OXDA_CRIGR; OXDA_HUMAN; OXDA_MACFA; OXDA_MOUSE; OXDA_PIG; OXDA_RABIT; OXDA_R | ChEBI |
| Melting_Point | ca 240? dec. | Alfa-Aesar |
| Melting_Point | ca 240° dec. | Alfa-Aesar |
| Patent Database Links | EP1422218; EP1586583; EP1649857; EP1657249; EP1844769; US2003064429; US2004034080; US2007213260; US2008027137; WO2005066135; WO2005066143; WO2007137224; WO2007137227 | ChEBI |
| SOLUBILITY | H2O: 0.1 g/mL, clear, colorless | Indofine |
| Reactome Database Links | REACT_14851 | ChEBI |
| S phrase | S24/25: Avoid contact with skin and eyes. | Acros Organics |
| Notes | USP, pyrogen freeCell culture tested | Apollo Scientific Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMDZ1-4-E | Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #4 Of 6), Eukaryotic | Eukaryotes | 670 | 1.23 | Binding ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 7), Other | Other | 300 | 1.30 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 670 | 1.23 | Binding ≤ 1μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 200 | 1.34 | Binding ≤ 1μM |
| NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 670 | 1.23 | Binding ≤ 10μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 200 | 1.34 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Amino acid transport across the plasma membrane |
| Description | Species |
|---|---|
| CREB phosphorylation through the activation of CaMKII | |
| EPHB-mediated forward signaling | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Unblocking of NMDA receptor, glutamate binding and activation |
No pre-computed analogs available. Try a structural similarity search.