In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
August 14th, 2007 | 22 | Yes |
Popular Name: 4-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]propyl}phenol 4-{1-hydroxy-2-[(1-methyl-3-phen…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.41 | -3.02 | -44.45 | 4 | 3 | 1 | 57 | 300.422 | 7 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
NMDE2-1-E | Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 180 | 0.43 | Functional ≤ 10μM |
NMDZ1-2-E | Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 180 | 0.43 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 180 | 0.43 | Functional ≤ 10μM |
NMDE2_RAT | Q00960 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Rat | 180 | 0.43 | Functional ≤ 10μM |
Description | Species |
---|---|
CREB phosphorylation through the activation of CaMKII | |
EPHB-mediated forward signaling | |
Ras activation uopn Ca2+ infux through NMDA receptor | |
Unblocking of NMDA receptor, glutamate binding and activation |