UCSF

ZINC94566092

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
July 18th, 2013 0 Yes

Popular Name: Doxazosin Doxazosin

Find On: PubMed — Wikipedia — Google

CAS Numbers: 104874-86-4 , 74191-85-8 , 77883-43-3 , [70918-01-3] , [74191-85-8]

Other Names:

azosin

1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin; 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin; C23H25N5O5; Cardura; Carduran; Doxazosin; Doxazosin [INN:BAN]; Doxazosina

1-(4-Amino-6,7-Dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazin; 1-(4-Amino-6,7-dimethoxy-2-chinazolinyl)-4-(2,3-dihydro-1,4-benzodioxixin-2-ylcarbonyl)piperazin; Doxazosin

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine monomethanesulfonate; 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzoldioxan-2-ylcarbonyl)piperazine methanesulfonate; Alfadil; Benur; C23H25N5O5.CH4O3S; CARDURA; Ca

2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine

2-[4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid

74191-85-8; C06970; Doxazosin

74191-85-8; Cardura XL (TN); D07874; Doxazosin (INN)

77883-43-3; Cardura (TN); D00608; Doxazosin mesilate (JP16); Doxazosin mesylate (USAN)

77883-43-3; Doxazosin mesylate; Prestwick_1026

Alfadil

BRD-A13188892-066-03-3

Cardenalin

Cardular

Cardura

Cardura XL

Cardura, Carduran

Cardura-1

Cardura-2

Cardura-4

Carduran

Carduran Neo

CPD000097306; Doxazosin; SAM002589981

Dedralen

Diblocin

Doxazosin (BAN

Doxazosin HCl

Doxazosin mesilate

Doxazosin mesylate

Doxazosin Mesylate (FDA

doxazosin; doxazosina; doxazosine; doxazosinum

INN); Doxazosin Mesilate (JAN)

INN); Doxazosin Mesilate (JAN); Doxazosin Mesylate (FDA

INN); Doxazosin Mesylate (FDA

LS-189931

MFCD00216023

MFCD00800482

MFCD03840627

N/A

Normothen

Piperazine,1- -4-[ carbonyl]-, -

Progandol

QA-8517

S-Doxazosin

Supressin

Tensiobas

UK-33274

UK-33274-27

UK-3327427; UK-33274-27

USAN)

USAN); Doxazosin (BAN

USAN); Doxazosin Mesilate (JAN)

Zoxan

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Vendor Notes

Note Type Comments Provided By
MP 279 - 281 Enamine Building Blocks
MP 279...281 Enamine Building Blocks
ALOGPS_SOLUBILITY 7.90e-01 g/l DrugBank-approved
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Target Adrenergic Receptor Selleck Chemicals
mechanism alpha-1-Adrenoceptor antagonist IBScreen Bioactives IBScreen Bioactives
mechanism Alters serum lipid profile via increase in LDL-receptor activity and other effects IBScreen Bioactives
Indications antihypertensive KeyOrganics Bioactives
biological_use Antihypertensive agent IBScreen Bioactives IBScreen Bioactives
Patent Database Links EP1106210; EP1162202; EP1629835; EP1649855; EP1671630; EP1746099; EP1862181; EP1889847; EP1894567; EP1988098; US2002061879; US2002143007; US2004254182; US2005014759; US2005043325; US2005065161; US2005065209; US2005137213; US2005187222; US2007112067; US200 ChEBI
PUBCHEM_SUBSTANCE_COMMENT NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : D-1598; NCC_SUPPLIER_SAMPLE_COMMENTS : WHITE POWDER NIH Clinical Collection via PubChem
PUBCHEM_SUBSTANCE_COMMENT SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: D-1598; SUPPLIER_COMMENTS: WHITE POWDER NIH Clinical Collection via PubChem
biological_use Used in the treatment of benign prostatic hyperplasia IBScreen Bioactives

Activity (Go SEA)

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.