UCSF

Cytochrome P450 1A1, Human (55 Compounds)

Swissprot:
CP1A1_HUMAN
Stitch:
CP1A1_HUMAN
UniProt:
P04798
ChEMBL:
CHEMBL2231
Reactome:
REACT_116145
REACT_150134
REACT_150417
REACT_13543
PDB:
CYP1A1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
ADME/T ≤ 10μM 55 36 30 10

Reactome Network (4)

Reactome ID Description Species
REACT_116145 PPARA activates gene expression Homo sapiens
REACT_150134 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Homo sapiens
REACT_150417 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Homo sapiens
REACT_13543 Xenobiotics Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 42
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 50
CP2C8_HUMAN P10632 CHEMBL3721 Cytochrome P450 2C8, Human 1
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 3
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 1

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Uniprot Swissprot Chembl Description Number Shared
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 42
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 50
CP2C8_HUMAN P10632 CHEMBL3721 Cytochrome P450 2C8, Human 1
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 3
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 1

Xenobiotics

Uniprot Swissprot Chembl Description Number Shared
CP2C8_HUMAN P10632 CHEMBL3721 Cytochrome P450 2C8, Human 1
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 3
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CP1B1_HUMAN Q16678 CHEMBL4878 Cytochrome P450 1B1, Human 43
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 42
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 3
CP2B1_RAT P00176 CHEMBL3335 Cytochrome P450 2B1, Rat 1
CP2C8_HUMAN P10632 CHEMBL3721 Cytochrome P450 2C8, Human 1
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 1
Z81115 Z81115 CHEMBL398 KB (Squamous Cell Carcinoma) 1