UCSF

Catenin Beta-1, Human (16 Compounds)

Swissprot:
CTNB1_HUMAN
Stitch:
CTNB1_HUMAN
UniProt:
P35222
ChEMBL:
CHEMBL5866
Reactome:
REACT_200799
REACT_172761
REACT_21402
REACT_200731
REACT_200610
REACT_200753
REACT_163743
REACT_228106
REACT_228159
REACT_228251
REACT_228137
REACT_228261
REACT_200777
PDB:
1G3J (DOCK)
1JDH (DOCK)
1JPW (DOCK)
1LUJ (DOCK)
1P22 (DOCK)
1QZ7 (DOCK)
1T08 (DOCK)
1TH1 (DOCK)
2G57 (DOCK)
2GL7 (DOCK)
2Z6H (DOCK)
3DIW (DOCK)
3FQN (DOCK)
3FQR (DOCK)
3TX7 (DOCK)
CTNNB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 16 0 0 0
Binding ≤ 1μM 4 0 0 0

Reactome Network (13)

Reactome ID Description Species
REACT_200799 binding of TCF/LEF:CTNNB1 to target gene promoters Homo sapiens
REACT_172761 Ca2+ pathway Homo sapiens
REACT_21402 CDO in myogenesis Homo sapiens
REACT_200731 deactivation of the beta-catenin transactivating complex Homo sapiens
REACT_200610 disassembly of the destruction complex and recruitment of AXIN to the membrane Homo sapiens
REACT_200753 formation of the beta-catenin:TCF transactivating complex Homo sapiens
REACT_163743 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Homo sapiens
REACT_228106 repression of WNT target genes Homo sapiens
REACT_228159 S33 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_228251 S37 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_228137 S45 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_228261 T41 mutants of beta-catenin aren't phosphorylated Homo sapiens
REACT_200777 TCF dependent signaling in response to WNT Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
TCF7_HUMAN P36402 CHEMBL1075124 Transcription Factor 7, Human 1

Ca2+ pathway

Uniprot Swissprot Chembl Description Number Shared
TCF7_HUMAN P36402 CHEMBL1075124 Transcription Factor 7, Human 1

deactivation of the beta-catenin transactivating complex

Uniprot Swissprot Chembl Description Number Shared
TCF7_HUMAN P36402 CHEMBL1075124 Transcription Factor 7, Human 1

formation of the beta-catenin:TCF transactivating complex

Uniprot Swissprot Chembl Description Number Shared
TCF7_HUMAN P36402 CHEMBL1075124 Transcription Factor 7, Human 1

repression of WNT target genes

Uniprot Swissprot Chembl Description Number Shared
TCF7_HUMAN P36402 CHEMBL1075124 Transcription Factor 7, Human 1

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
CTNB1-1-E Catenin Beta-1 (cluster #1 Of 2), Eukaryotic 1 0 0 0
CTNB1-2-E Catenin Beta-1 (cluster #2 Of 2), Eukaryotic 15 0 0 0
Uniprot Swissprot Chembl Description Number Shared
WNT2_HUMAN P09544 CHEMBL1255132 Protein Wnt-2, Human 15
PSMG1_HUMAN O95456 CHEMBL1075122 Proteasome Assembly Chaperone 1, Human 1
PSMG2_HUMAN Q969U7 CHEMBL1075123 Proteasome Assembly Chaperone 2, Human 1
PSMG3_HUMAN Q9BT73 CHEMBL1075137 Proteasome Assembly Chaperone 3, Human 1
TCF7_HUMAN P36402 CHEMBL1075124 Transcription Factor 7, Human 1

Most Common Rings