UCSF

NF-kappaB Inhibitor Alpha, Human (38 Compounds)

Swissprot:
IKBA_HUMAN
Stitch:
IKBA_HUMAN
UniProt:
P25963
ChEMBL:
CHEMBL2898
Reactome:
REACT_118656
REACT_12555
REACT_163994
REACT_13696
REACT_118563
REACT_21281
REACT_24969
PDB:
1IKN (DOCK)
1NFI (DOCK)
NFKBIA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 38 13 0 0
Binding ≤ 1μM 4 2 0 0

Reactome Network (7)

Reactome ID Description Species
REACT_118656 Activation of NF-kappaB in B cells Homo sapiens
REACT_12555 Downstream TCR signaling Homo sapiens
REACT_163994 FCERI mediated NF-kB activation Homo sapiens
REACT_13696 NF-kB is activated and signals survival Homo sapiens
REACT_118563 RIP-mediated NFkB activation via ZBP1 Homo sapiens
REACT_21281 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens
REACT_24969 TRAF6 mediated NF-kB activation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKBE_HUMAN O00221 CHEMBL3407 NF-kappaB Inhibitor Epsilon, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27

Downstream TCR signaling

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27

FCERI mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27

NF-kB is activated and signals survival

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27

RIP-mediated NFkB activation via ZBP1

Uniprot Swissprot Chembl Description Number Shared
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Uniprot Swissprot Chembl Description Number Shared
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27

TRAF6 mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 27
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKBE_HUMAN O00221 CHEMBL3407 NF-kappaB Inhibitor Epsilon, Human 8
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 8
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 8
Z100256 Z100256 CHEMBL612443 Proteasome 1