UCSF

Nuclear Factor NF-kappa-B P65 Subunit, Human (45 Compounds)

Swissprot:
TF65_HUMAN
Stitch:
TF65_HUMAN
UniProt:
Q04206
ChEMBL:
CHEMBL5533
Reactome:
REACT_118656
REACT_163773
REACT_12555
REACT_163994
REACT_23950
REACT_13696
REACT_13443
REACT_118563
REACT_169168
REACT_21281
REACT_24969
REACT_27161
PDB:
1NFI (DOCK)
2O61 (DOCK)
3GUT (DOCK)
3QXY (DOCK)
3RC0 (DOCK)
RELA

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 45 15 4 0
Binding ≤ 1μM 17 4 1 0
Functional ≤ 10μM 26 0 0 0

Reactome Network (12)

Reactome ID Description Species
REACT_118656 Activation of NF-kappaB in B cells Homo sapiens
REACT_163773 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Homo sapiens
REACT_12555 Downstream TCR signaling Homo sapiens
REACT_163994 FCERI mediated NF-kB activation Homo sapiens
REACT_23950 Interleukin-1 processing Homo sapiens
REACT_13696 NF-kB is activated and signals survival Homo sapiens
REACT_13443 Regulated proteolysis of p75NTR Homo sapiens
REACT_118563 RIP-mediated NFkB activation via ZBP1 Homo sapiens
REACT_169168 Senescence-Associated Secretory Phenotype (SASP) Homo sapiens
REACT_21281 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens
REACT_24969 TRAF6 mediated NF-kB activation Homo sapiens
REACT_27161 Transcriptional regulation of white adipocyte differentiation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28

DEx/H-box helicases activate type I IFN and inflammatory cytokines production

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 26

Downstream TCR signaling

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28

FCERI mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
TAB1_HUMAN Q15750 CHEMBL5605 Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1, Human 1

Interleukin-1 processing

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 26

NF-kB is activated and signals survival

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28

Regulated proteolysis of p75NTR

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28

RIP-mediated NFkB activation via ZBP1

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 26

Senescence-Associated Secretory Phenotype (SASP)

Uniprot Swissprot Chembl Description Number Shared
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 24
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 24
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
MK03_HUMAN P27361 CHEMBL3385 MAP Kinase ERK1, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 26
TAB1_HUMAN Q15750 CHEMBL5605 Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1, Human 1

TRAF6 mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 26

Transcriptional regulation of white adipocyte differentiation

Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
TF_HUMAN P13726 CHEMBL4081 Coagulation Factor III, Human 363 4 2 3

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
TF65-1-E Nuclear Factor NF-kappa-B P65 Subunit (cluster #1 Of 3), Eukaryotic 10 1 4 0
TF65-2-E Nuclear Factor NF-kappa-B P65 Subunit (cluster #2 Of 3), Eukaryotic 4 0 0 0
TF65-3-E Nuclear Factor NF-kappa-B P65 Subunit (cluster #3 Of 3), Eukaryotic 31 14 0 0
Uniprot Swissprot Chembl Description Number Shared
NFKB1_HUMAN P19838 CHEMBL3251 Nuclear Factor NF-kappa-B P105 Subunit, Human 28
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 27
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 26
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 24
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 24
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 24
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 1
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 1
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 1
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
M3K7_HUMAN O43318 CHEMBL5776 Mitogen-activated Protein Kinase Kinase Kinase 7, Human 1
MK01_HUMAN P28482 CHEMBL4040 MAP Kinase ERK2, Human 1
MK03_HUMAN P27361 CHEMBL3385 MAP Kinase ERK1, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
NANH_CLOPE P10481 CHEMBL5189 Sialidase, Clope 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
TAB1_HUMAN Q15750 CHEMBL5605 Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1