UCSF

Retinoid X Receptor Alpha, Mouse (24 Compounds)

Swissprot:
RXRA_MOUSE
Stitch:
RXRA_MOUSE
UniProt:
P28700
ChEMBL:
CHEMBL3084
Reactome:
REACT_198969
REACT_198620
REACT_241925
REACT_227038
REACT_257268
REACT_234105
REACT_198602
REACT_239346
REACT_257219
REACT_226284
REACT_198352
REACT_198351
REACT_207530
REACT_226440
REACT_203193
REACT_205251
REACT_27166
REACT_252217
REACT_196516
PDB:
1DKF (DOCK)
1XDK (DOCK)
3A9E (DOCK)
Rxra

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 24 4 3 3
Binding ≤ 1μM 18 4 3 3
Functional ≤ 10μM 3 0 0 0

Reactome Network (19)

Reactome ID Description Species
REACT_198969 Activation of gene expression by SREBF (SREBP) Mus musculus
REACT_198620 BMAL1:CLOCK,NPAS2 activates circadian gene expression Mus musculus
REACT_241925 Circadian Clock Mus musculus
REACT_227038 Endogenous sterols Mus musculus
REACT_257268 Import of palmitoyl-CoA into the mitochondrial matrix Mus musculus
REACT_234105 Nuclear Receptor transcription pathway Mus musculus
REACT_198602 PPARA activates gene expression Mus musculus
REACT_239346 Recycling of bile acids and salts Mus musculus
REACT_257219 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp Mus musculus
REACT_226284 Regulation of pyruvate dehydrogenase (PDH) complex Mus musculus
REACT_198352 REV-ERBA represses gene expression Mus musculus
REACT_198351 RORA activates circadian gene expression Mus musculus
REACT_207530 Synthesis of bile acids and bile salts Mus musculus
REACT_226440 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Mus musculus
REACT_203193 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Mus musculus
REACT_205251 Transcriptional activation of mitochondrial biogenesis Mus musculus
REACT_27166 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes Mus musculus
REACT_252217 Transcriptional regulation of white adipocyte differentiation Mus musculus
REACT_196516 YAP1- and WWTR1 (TAZ)-stimulated gene expression Mus musculus
Uniprot Swissprot Chembl Description Number Shared
RABP1_MOUSE P62965 CHEMBL3208 Cellular Retinoic Acid-binding Protein I, Mouse 5
RABP2_MOUSE P22935 CHEMBL4172 Cellular Retinoic Acid-binding Protein II, Mouse 5

Nuclear Receptor transcription pathway

Uniprot Swissprot Chembl Description Number Shared
RARA_MOUSE P11416 CHEMBL2792 Retinoic Acid Receptor Alpha, Mouse 14
RARB_MOUSE P22605 CHEMBL3266 Retinoic Acid Receptor Beta, Mouse 13
RARG_MOUSE P18911 CHEMBL4177 Retinoic Acid Receptor Gamma, Mouse 13
RXRB_MOUSE P28704 CHEMBL4047 Retinoid X Receptor Beta, Mouse 18
RXRG_MOUSE P28705 CHEMBL4402 Retinoid X Receptor Gamma, Mouse 18

Regulation of pyruvate dehydrogenase (PDH) complex

Uniprot Swissprot Chembl Description Number Shared
RABP1_MOUSE P62965 CHEMBL3208 Cellular Retinoic Acid-binding Protein I, Mouse 5
RABP2_MOUSE P22935 CHEMBL4172 Cellular Retinoic Acid-binding Protein II, Mouse 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 344 15 7 6
RXRA_RAT Q05343 CHEMBL4431 Retinoid X Receptor Alpha, Rat 19 4 3 3

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
RXRB_MOUSE P28704 CHEMBL4047 Retinoid X Receptor Beta, Mouse 18
RXRG_MOUSE P28705 CHEMBL4402 Retinoid X Receptor Gamma, Mouse 18
RARA_MOUSE P11416 CHEMBL2792 Retinoic Acid Receptor Alpha, Mouse 14
RXRA_HUMAN P19793 CHEMBL2061 Retinoid X Receptor Alpha, Human 14
RARB_MOUSE P22605 CHEMBL3266 Retinoic Acid Receptor Beta, Mouse 13
RARG_MOUSE P18911 CHEMBL4177 Retinoic Acid Receptor Gamma, Mouse 13
RXRB_HUMAN P28702 CHEMBL1870 Retinoid X Receptor Beta, Human 10
RXRG_HUMAN P48443 CHEMBL2004 Retinoid X Receptor Gamma, Human 10
RARB_HUMAN P10826 CHEMBL2008 Retinoic Acid Receptor Beta, Human 9
RARA_HUMAN P10276 CHEMBL2055 Retinoic Acid Receptor Alpha, Human 8
RARG_HUMAN P13631 CHEMBL2003 Retinoic Acid Receptor Gamma, Human 7
RABP1_MOUSE P62965 CHEMBL3208 Cellular Retinoic Acid-binding Protein I, Mouse 5
RABP2_MOUSE P22935 CHEMBL4172 Cellular Retinoic Acid-binding Protein II, Mouse 5
RABP1_CHICK P40220 CHEMBL4945 Cellular Retinoic Acid-binding Protein I, Chick 3
RXRA_RAT Q05343 CHEMBL4431 Retinoid X Receptor Alpha, Rat 3
D3ZWV0_RAT D3ZWV0 CHEMBL2630 Retinoic Acid Receptor Gamma, Rat 1