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    • Search Results | ZINC Is Not Commercial - A database of commercially-available compounds
    UCSF
    ZINC Item Suppliers, Protomers, & Similar Substances

    Analogs

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    Popular Name:

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    Clustered Target Annotations
    Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
    SRBP2-1-E Sterol Regulatory Element-binding Protein 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 9800 0.33 Binding ≤ 10μM

    Physical Representations

    Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
    Ref Reference (pH 7) 5.49 10.14 -6.51 0 2 0 26 359.292 4 ↓

    Analogs

    8040482
    8040482

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    Popular Name: 2-(2-Propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide 2-(2-Propylpyridin-4-yl)-4-(p-to…

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    Clustered Target Annotations
    Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
    SRBP2-1-E Sterol Regulatory Element-binding Protein 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 5600 0.35 Binding ≤ 10μM

    Physical Representations

    Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
    Ref Reference (pH 7) 5.13 10.19 -6.91 0 2 0 26 294.423 4 ↓

    Analogs

    1532563
    1532563
    1704723
    1704723
    1745010
    1745010

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    Popular Name: 25-Hydroxycholesterol 25-Hydroxycholesterol

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    Clustered Target Annotations
    Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
    NR1H3-2-E LXR-alpha (cluster #2 Of 2), Eukaryotic Eukaryotes 1160 0.29 Binding ≤ 10μM
    SRBP2-2-E Sterol Regulatory Element-binding Protein 2 (cluster #2 Of 2), Eukaryotic Eukaryotes 300 0.31 Binding ≤ 10μM

    Physical Representations

    Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
    Ref Reference (pH 7) 6.42 9.51 -3.39 2 2 0 40 402.663 5 ↓

    Analogs

    Draw Identity 99% 90% 80% 70%

    Popular Name: 4-[4-(2-methoxyphenyl)thiazol-2-yl]-2-propyl-pyridine 4-[4-(2-methoxyphenyl)thiazol-2-…

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    And 5 More

    Activity (Go SEA)

    Clustered Target Annotations
    Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
    SRBP2-1-E Sterol Regulatory Element-binding Protein 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 3200 0.35 Binding ≤ 10μM

    Physical Representations

    Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
    Ref Reference (pH 7) 4.69 0.64 -8.97 0 3 0 35 310.422 5 ↓

    Parameters Provided:

    annotation.name = SRBP2_HUMAN
anotation.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

    Structural Results Found: (before additional filtering)

    SQL Query Was

    SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN note AS n ON ci.sub_id_fk=n.sub_id_fk INNER JOIN annotation AS a ON n.anno_id_fk=a.anno_id  WHERE c.free = 1 AND a.short_desc LIKE 'SRBP2\\_HUMAN' AND c.purchasable IN (1,2,4,5)    LIMIT 50

    Permalink

    //zinc12.docking.org/results/combination?annotation.name=SRBP2_HUMAN&filter.purchasability=purchasable

    Embed Link to Results

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