| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 3rd, 2005 | 12 | Yes |
Popular Name: Nicotine Nicotine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 21361-93-3; 54-11-5 , 22083-74-5 , 2624-48-8 , 29790-52-1 , 54-11-5 , 6019-06-3 , 65-31-6 , 6505-86-8 , 6550-19-2 , 98-80-6 , [29790-52-1] , [54-11-5] , [65-30-5]
(+-)-nicotine; (R,S)-nicotine; (RS)-nicotine; Nicotin; Nikotin
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-3-(1-Methylpyrrolidin-2-yl)pyridine
(S)-3-(1-Methylpyrrolidin-2-yl)pyridine (2R,3R)-2,3-dihydroxysuccinate
(S)-3-(1-Methylpyrrolidin-2-yl)pyridine 2-hydroxybenzoate
(S)-3-(1-Methylpyrrolidin-2-yl)pyridine; (S)-Nicotine; 54-11-5; C00745; Nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine; 54-11-5; Nicotine; bmse000105
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-nicotine; (S)-nicotinium cation
)-1-Methyl-2-(3-pyridyl)pyrrolidine
3-(1-methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
434F7990-3240-4A43-ACEC-E6CC1E495FA0
54-11-5; CPD000059074; NICOTINE; SAM002564224
beta-Pyridyl-alpha-N-methyl pyrrolidine
CHEBI:44268; CHEBI:14653; CHEBI:25536; CHEBI:7562
CPD000059074; NICOTINE; SAM002564224
D05156; Nicotine bitartrate (USAN); Nicotine bitartrate dihydrate
EPA Pesticide Chemical Code 056702
http://www.selleckchem.com/products/nicotiN/A
Nicotine (compounds related to)
Nicotine ditartrate dihydrate, 98%
Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-
Pyridine, 3-(1-methyl-2-pyrrolidinyl)-
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.09 | 5.14 | -35.14 | 1 | 2 | 1 | 17 | 163.244 | 1 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Molecular_Solubility | 1.591 | Bitter DB |
| Melting_Point | 79? | Alfa-Aesar |
| Melting_Point | 79° | Alfa-Aesar |
| Mp [°C] | 80 | Acros Organics |
| Boiling_Point | 245-248? | Alfa-Aesar |
| Boiling_Point | 245-248° | Alfa-Aesar |
| BP [°C] | 247 | Acros Organics |
| ALOGPS_SOLUBILITY | 9.33e+01 g/l | DrugBank-approved |
| purity | 9.500000000000000e+001 | Enamine Building Blocks |
| BP | 91 / 3 | TCI |
| purity | 95 | Enamine Building Blocks |
| Purity | 95% | Fluorochem |
| Mp [°C] | 97 - 100 | Acros Organics |
| UniProt Database Links | ACH23_CAEEL; ACH8_CAEEL; CAS2_CONST; CP1A2_HUMAN; CP2A6_HUMAN; DEND_RAT; DHPON_ARTNI; GNAT3_BOVIN; HDNO_ARTOX; HSPA_PSEPU; HSPB_PSEPU; LYNX1_MACMU; LYNX1_MOUSE; MABO1_ARTNI; MABO2_ARTNI; MOODY_DROME; NBOR_ARTNI; NICA_PSEPU; NIT_ARTNI; NXL1A_BUNMU; NXL1_NA | ChEBI |
| PUBCHEM_PATENT_ID | EP0630904A1; WO1994004547A1 | IBM Patent Data |
| Patent Database Links | EP0814084; EP0821959; EP0857725; EP0881224; EP0891978; EP0924205; EP0955301; EP0974363; EP1055665; EP1072254; EP1074549; EP1078637; EP1083178; EP1088550; EP1130018; EP1176143; EP1178045; EP1178047; EP1178048; EP1190721; EP1211247; EP1213291; EP1231212; EP | ChEBI |
| H phrase | H301: Toxic if swallowed | Acros Organics |
| H phrase | H301: Toxic if swallowed; H411: Toxic to aquatic life with long lasting effects; H310: Fatal in contact with skin; H330: Fatal if inhaled | Acros Organics |
| H phrase | H411: Toxic to aquatic life with long lasting effects | Acros Organics |
| H phrase | H411: Toxic to aquatic life with long lasting effects; H310: Fatal in contact with skin; H301: Toxic if swallowed | Acros Organics |
| Target | Insulin(P01308)&Phosphoenolpyruvate carboxykinase, cytosolic [GTP](P35558)&Glucokinase(P35557)&Tumor necrosis factor(P01375)&Prostaglandin G/H synthase 2(P35354)&Indolethylamine N-methyltransferase(O95050)&Somatotropin(P01241)&Hormone-sensitive lipase(Q05 | Herbal Ingredients Targets |
| PUBCHEM_SUBSTANCE_COMMENT | NCC_SAMPLE_SUPPLIER : LightBiologicals; NCC_SUPPLIER_STRUCTURE_ID : N-3255; NCC_SUPPLIER_SAMPLE_COMMENTS : FAINTLY BROWNISH-YELLOW LIQUID | NIH Clinical Collection via PubChem |
| Therapy | nicotinyl acetylchloline receptor agonist, ectoparasiticide | SMDC MicroSource |
| Target | Others | Selleck Chemicals |
| P phrase | P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician | Acros Organics |
| P phrase | P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician; P280: Wear protective gloves/protective clothing/eye protection/face protection; P361: Remove/Take off immediately all contaminated clothing; P302 + P350: IF ON SKIN: Gently | Acros Organics |
| R phrase | R25: Toxic if swallowed. | Acros Organics |
| R phrase | R25: Toxic if swallowed.; R26/27: Very toxic by inhalation and in contact with skin.; R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. | Acros Organics |
| R phrase | R25: Toxic if swallowed.; R27: Very toxic in contact with skin.; R51/53: Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. | Acros Organics |
| Reactome Database Links | REACT_6956 | ChEBI |
| S phrase | S13: Keep away from food, drink and animal feedingstuffs. | Acros Organics |
| S phrase | S13: Keep away from food, drink and animal feedingstuffs.; S28A: After contact with skin, wash immediately with plenty of water.; S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).; S61: Avoid | Acros Organics |
| S phrase | S36/37: Wear suitable protective clothing and gloves. | Acros Organics |
| S phrase | S36/37: Wear suitable protective clothing and gloves.; S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).; S61: Avoid release to the environment. Refer to special instructions / safety data she | Acros Organics |
| PUBCHEM_SUBSTANCE_COMMENT | SAMPLE_SUPPLIER: LightBiologicals; SUPPLIER_STRUCTURE_ID: N-3255; SUPPLIER_COMMENTS: FAINTLY BROWNISH-YELLOW LIQUID | NIH Clinical Collection via PubChem |
| Hazard | T+: Very toxic | Acros Organics |
| Hazard | T+: Very toxic; N: Dangerous for the environment | Acros Organics |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ACH10-2-E | Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit (cluster #2 Of 4), Eukaryotic | Eukaryotes | 8 | 0.94 | Binding ≤ 10μM |
| ACHA-4-E | Acetylcholine Receptor Protein Alpha Chain (cluster #4 Of 4), Eukaryotic | Eukaryotes | 7 | 0.95 | Binding ≤ 10μM |
| ACHA2-4-E | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit (cluster #4 Of 6), Eukaryotic | Eukaryotes | 12 | 0.92 | Binding ≤ 10μM |
| ACHA3-4-E | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit (cluster #4 Of 5), Eukaryotic | Eukaryotes | 47 | 0.85 | Binding ≤ 10μM |
| ACHA4-1-E | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #1 Of 5), Eukaryotic | Eukaryotes | 5500 | 0.61 | Binding ≤ 10μM |
| ACHA5-4-E | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit (cluster #4 Of 4), Eukaryotic | Eukaryotes | 7 | 0.95 | Binding ≤ 10μM |
| ACHA6-4-E | Neuronal Acetylcholine Receptor Subunit Alpha-6 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 7 | 0.95 | Binding ≤ 10μM |
| ACHA7-1-E | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit (cluster #1 Of 6), Eukaryotic | Eukaryotes | 770 | 0.71 | Binding ≤ 10μM |
| ACHA9-4-E | Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit (cluster #4 Of 4), Eukaryotic | Eukaryotes | 7 | 0.95 | Binding ≤ 10μM |
| ACHB-1-E | Acetylcholine Receptor Protein Beta Chain (cluster #1 Of 4), Eukaryotic | Eukaryotes | 7 | 0.95 | Binding ≤ 10μM |
| ACHB2-4-E | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit (cluster #4 Of 7), Eukaryotic | Eukaryotes | 5500 | 0.61 | Binding ≤ 10μM |
| ACHB3-4-E | Neuronal Acetylcholine Receptor Subunit Beta-3 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 2000 | 0.66 | Binding ≤ 10μM |
| ACHB4-5-E | Neuronal Acetylcholine Receptor Subunit Beta-4 (cluster #5 Of 7), Eukaryotic | Eukaryotes | 5000 | 0.62 | Binding ≤ 10μM |
| ACHD-1-E | Acetylcholine Receptor Protein Delta Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 6300 | 0.61 | Binding ≤ 10μM |
| ACHG-1-E | Acetylcholine Receptor Protein Gamma Chain (cluster #1 Of 3), Eukaryotic | Eukaryotes | 6300 | 0.61 | Binding ≤ 10μM |
| ACHP-2-E | Acetylcholine-binding Protein (cluster #2 Of 3), Eukaryotic | Eukaryotes | 63 | 0.84 | Binding ≤ 10μM |
| KCNH2-5-E | HERG (cluster #5 Of 5), Eukaryotic | Eukaryotes | 3610 | 0.63 | Binding ≤ 10μM |
| Q8BGP7-1-E | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3 | 0.99 | Binding ≤ 10μM |
| ACHA3-2-E | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit (cluster #2 Of 3), Eukaryotic | Eukaryotes | 9400 | 0.59 | Functional ≤ 10μM |
| ACHA4-2-E | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 6600 | 0.60 | Functional ≤ 10μM |
| ACHA7-3-E | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit (cluster #3 Of 4), Eukaryotic | Eukaryotes | 1500 | 0.68 | Functional ≤ 10μM |
| ACHD-1-E | Acetylcholine Receptor Protein Delta Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7100 | 0.60 | Functional ≤ 10μM |
| CP2A6-1-E | Cytochrome P450 2A6 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 4400 | 0.62 | ADME/T ≤ 10μM |
| Z104281-2-O | Neuronal Acetylcholine Receptor; Alpha3/beta2 (cluster #2 Of 2), Other | Other | 47 | 0.85 | Binding ≤ 10μM |
| Z104282-1-O | Acetylcholine Receptor; Alpha1/beta1/delta/gamma (cluster #1 Of 1), Other | Other | 6270 | 0.61 | Binding ≤ 10μM |
| Z104283-1-O | Neuronal Acetylcholine Receptor; Alpha4/beta2 (cluster #1 Of 4), Other | Other | 9 | 0.94 | Binding ≤ 10μM |
| Z104284-1-O | Neuronal Acetylcholine Receptor; Alpha2/beta4 (cluster #1 Of 1), Other | Other | 70 | 0.83 | Binding ≤ 10μM |
| Z104285-1-O | Neuronal Acetylcholine Receptor; Alpha4/beta4 (cluster #1 Of 1), Other | Other | 129 | 0.80 | Binding ≤ 10μM |
| Z104286-2-O | Neuronal Acetylcholine Receptor; Alpha2/beta2 (cluster #2 Of 2), Other | Other | 6 | 0.96 | Binding ≤ 10μM |
| Z104287-3-O | Neuronal Acetylcholine Receptor; Alpha3/beta4 (cluster #3 Of 3), Other | Other | 530 | 0.73 | Binding ≤ 10μM |
| Z104288-1-O | Neuronal Acetylcholine Receptor; Alpha3/beta4 (cluster #1 Of 2), Other | Other | 530 | 0.73 | Binding ≤ 10μM |
| Z104289-2-O | Neuronal Acetylcholine Receptor; Alpha4/beta4 (cluster #2 Of 2), Other | Other | 46 | 0.86 | Binding ≤ 10μM |
| Z104290-1-O | Neuronal Acetylcholine Receptor; Alpha4/beta2 (cluster #1 Of 4), Other | Other | 10 | 0.93 | Binding ≤ 10μM |
| Z50594-1-O | Mus Musculus (cluster #1 Of 1), Other | Other | 1 | 1.05 | Binding ≤ 10μM |
| Z104283-1-O | Neuronal Acetylcholine Receptor; Alpha4/beta2 (cluster #1 Of 2), Other | Other | 9400 | 0.59 | Functional ≤ 10μM |
| Z104288-1-O | Neuronal Acetylcholine Receptor; Alpha3/beta4 (cluster #1 Of 1), Other | Other | 8000 | 0.59 | Functional ≤ 10μM |
| Z104290-1-O | Neuronal Acetylcholine Receptor; Alpha4/beta2 (cluster #1 Of 1), Other | Other | 7 | 0.95 | Functional ≤ 10μM |
| Z50597-1-O | Rattus Norvegicus (cluster #1 Of 12), Other | Other | 40 | 0.86 | Functional ≤ 10μM |
| Z81074-1-O | K177cell Line (cluster #1 Of 1), Other | Other | 5000 | 0.62 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ACHA_RAT | P25108 | Acetylcholine Receptor Protein Alpha Chain, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHA_TORCA | P02710 | Acetylcholine Receptor Protein Alpha Chain, Torca | 1 | 1.05 | Binding ≤ 1μM |
| ACHB_RAT | P25109 | Acetylcholine Receptor Protein Beta Chain, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHB_TORCA | P02712 | Acetylcholine Receptor Protein Beta Chain, Torca | 1 | 1.05 | Binding ≤ 1μM |
| ACHD_TORCA | P02718 | Acetylcholine Receptor Protein Delta Chain, Torca | 1 | 1.05 | Binding ≤ 1μM |
| ACHG_TORCA | P02714 | Acetylcholine Receptor Protein Gamma Chain, Torca | 1 | 1.05 | Binding ≤ 1μM |
| ACHP_LYMST | P58154 | Acetylcholine-binding Protein, Lymst | 331.131121 | 0.76 | Binding ≤ 1μM |
| Z50594 | Z50594 | Mus Musculus | 1.41 | 1.03 | Binding ≤ 1μM |
| ACH10_RAT | Q9JLB5 | Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Rat | 0.1 | 1.17 | Binding ≤ 1μM |
| ACHA2_RAT | P12389 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHA2_HUMAN | Q15822 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human | 103 | 0.82 | Binding ≤ 1μM |
| ACHA3_HUMAN | P32297 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 220 | 0.78 | Binding ≤ 1μM |
| ACHA3_RAT | P04757 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Rat | 0.1 | 1.17 | Binding ≤ 1μM |
| ACHA4_RAT | P09483 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat | 0.1 | 1.17 | Binding ≤ 1μM |
| ACHA4_MOUSE | O70174 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Mouse | 2.5 | 1.00 | Binding ≤ 1μM |
| ACHA4_HUMAN | P43681 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Human | 40 | 0.86 | Binding ≤ 1μM |
| ACHA5_RAT | P20420 | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHA6_RAT | P43143 | Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHA7_HUMAN | P36544 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human | 1.06 | 1.05 | Binding ≤ 1μM |
| ACHA7_RAT | Q05941 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHA7_MOUSE | P49582 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Mouse | 480 | 0.74 | Binding ≤ 1μM |
| ACHA9_RAT | P43144 | Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHB2_RAT | P12390 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| Q8BGP7_MOUSE | Q8BGP7 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Mouse | 2.5 | 1.00 | Binding ≤ 1μM |
| ACHB2_HUMAN | P17787 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human | 12 | 0.92 | Binding ≤ 1μM |
| ACHB3_RAT | P12391 | Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| ACHB4_HUMAN | P30926 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human | 103 | 0.82 | Binding ≤ 1μM |
| ACHB4_RAT | P12392 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 1μM |
| Z104286 | Z104286 | Neuronal Acetylcholine Receptor; Alpha2/beta2 | 12 | 0.92 | Binding ≤ 1μM |
| Z104284 | Z104284 | Neuronal Acetylcholine Receptor; Alpha2/beta4 | 110 | 0.81 | Binding ≤ 1μM |
| Z104281 | Z104281 | Neuronal Acetylcholine Receptor; Alpha3/beta2 | 1 | 1.05 | Binding ≤ 1μM |
| Z104288 | Z104288 | Neuronal Acetylcholine Receptor; Alpha3/beta4 | 320 | 0.76 | Binding ≤ 1μM |
| Z104287 | Z104287 | Neuronal Acetylcholine Receptor; Alpha3/beta4 | 220 | 0.78 | Binding ≤ 1μM |
| Z104283 | Z104283 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 1.01 | 1.05 | Binding ≤ 1μM |
| Z104290 | Z104290 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 1.5 | 1.03 | Binding ≤ 1μM |
| Z104289 | Z104289 | Neuronal Acetylcholine Receptor; Alpha4/beta4 | 23 | 0.89 | Binding ≤ 1μM |
| Z104285 | Z104285 | Neuronal Acetylcholine Receptor; Alpha4/beta4 | 129 | 0.80 | Binding ≤ 1μM |
| ACHA_RAT | P25108 | Acetylcholine Receptor Protein Alpha Chain, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHA_TORCA | P02710 | Acetylcholine Receptor Protein Alpha Chain, Torca | 1 | 1.05 | Binding ≤ 10μM |
| ACHB_RAT | P25109 | Acetylcholine Receptor Protein Beta Chain, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHB_TORCA | P02712 | Acetylcholine Receptor Protein Beta Chain, Torca | 1 | 1.05 | Binding ≤ 10μM |
| ACHD_TORCA | P02718 | Acetylcholine Receptor Protein Delta Chain, Torca | 1 | 1.05 | Binding ≤ 10μM |
| ACHD_HUMAN | Q07001 | Acetylcholine Receptor Protein Delta Chain, Human | 6300 | 0.61 | Binding ≤ 10μM |
| ACHG_TORCA | P02714 | Acetylcholine Receptor Protein Gamma Chain, Torca | 1 | 1.05 | Binding ≤ 10μM |
| Z104282 | Z104282 | Acetylcholine Receptor; Alpha1/beta1/delta/gamma | 1480 | 0.68 | Binding ≤ 10μM |
| ACHP_LYMST | P58154 | Acetylcholine-binding Protein, Lymst | 331.131121 | 0.76 | Binding ≤ 10μM |
| KCNH2_HUMAN | Q12809 | HERG, Human | 3610 | 0.63 | Binding ≤ 10μM |
| Z50594 | Z50594 | Mus Musculus | 1.41 | 1.03 | Binding ≤ 10μM |
| ACH10_RAT | Q9JLB5 | Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Rat | 0.1 | 1.17 | Binding ≤ 10μM |
| ACHA2_HUMAN | Q15822 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human | 103 | 0.82 | Binding ≤ 10μM |
| ACHA2_RAT | P12389 | Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHA3_HUMAN | P32297 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 2000 | 0.66 | Binding ≤ 10μM |
| ACHA3_RAT | P04757 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Rat | 0.1 | 1.17 | Binding ≤ 10μM |
| ACHA4_RAT | P09483 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat | 0.1 | 1.17 | Binding ≤ 10μM |
| ACHA4_MOUSE | O70174 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Mouse | 2.5 | 1.00 | Binding ≤ 10μM |
| ACHA4_HUMAN | P43681 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Human | 2000 | 0.66 | Binding ≤ 10μM |
| ACHA5_RAT | P20420 | Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHA6_RAT | P43143 | Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHA7_HUMAN | P36544 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human | 1.06 | 1.05 | Binding ≤ 10μM |
| ACHA7_RAT | Q05941 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHA7_MOUSE | P49582 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Mouse | 480 | 0.74 | Binding ≤ 10μM |
| ACHA9_RAT | P43144 | Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| Q8BGP7_MOUSE | Q8BGP7 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Mouse | 2.5 | 1.00 | Binding ≤ 10μM |
| ACHB2_HUMAN | P17787 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human | 12 | 0.92 | Binding ≤ 10μM |
| ACHB2_RAT | P12390 | Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHB3_HUMAN | Q05901 | Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Human | 2000 | 0.66 | Binding ≤ 10μM |
| ACHB3_RAT | P12391 | Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| ACHB4_HUMAN | P30926 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human | 103 | 0.82 | Binding ≤ 10μM |
| ACHB4_RAT | P12392 | Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat | 1.1 | 1.05 | Binding ≤ 10μM |
| Z104286 | Z104286 | Neuronal Acetylcholine Receptor; Alpha2/beta2 | 12 | 0.92 | Binding ≤ 10μM |
| Z104284 | Z104284 | Neuronal Acetylcholine Receptor; Alpha2/beta4 | 110 | 0.81 | Binding ≤ 10μM |
| Z104281 | Z104281 | Neuronal Acetylcholine Receptor; Alpha3/beta2 | 1 | 1.05 | Binding ≤ 10μM |
| Z104288 | Z104288 | Neuronal Acetylcholine Receptor; Alpha3/beta4 | 320 | 0.76 | Binding ≤ 10μM |
| Z104287 | Z104287 | Neuronal Acetylcholine Receptor; Alpha3/beta4 | 220 | 0.78 | Binding ≤ 10μM |
| Z104283 | Z104283 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 1.01 | 1.05 | Binding ≤ 10μM |
| Z104290 | Z104290 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 1.5 | 1.03 | Binding ≤ 10μM |
| Z104289 | Z104289 | Neuronal Acetylcholine Receptor; Alpha4/beta4 | 23 | 0.89 | Binding ≤ 10μM |
| Z104285 | Z104285 | Neuronal Acetylcholine Receptor; Alpha4/beta4 | 129 | 0.80 | Binding ≤ 10μM |
| ACHD_TORCA | P02718 | Acetylcholine Receptor Protein Delta Chain, Torca | 10000 | 0.58 | Functional ≤ 10μM |
| Z81074 | Z81074 | K177cell Line | 5000 | 0.62 | Functional ≤ 10μM |
| ACHA3_HUMAN | P32297 | Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human | 9400 | 0.59 | Functional ≤ 10μM |
| ACHA4_HUMAN | P43681 | Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Human | 4700 | 0.62 | Functional ≤ 10μM |
| ACHA7_RAT | Q05941 | Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat | 1500 | 0.68 | Functional ≤ 10μM |
| Z104288 | Z104288 | Neuronal Acetylcholine Receptor; Alpha3/beta4 | 4300 | 0.63 | Functional ≤ 10μM |
| Z104290 | Z104290 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 10000 | 0.58 | Functional ≤ 10μM |
| Z104283 | Z104283 | Neuronal Acetylcholine Receptor; Alpha4/beta2 | 290 | 0.76 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 40 | 0.86 | Functional ≤ 10μM |
| CP2A6_HUMAN | P11509 | Cytochrome P450 2A6, Human | 4400 | 0.62 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| Glucuronidation |
| Description | Species |
|---|---|
| CYP2E1 reactions | |
| Highly calcium permeable nicotinic acetylcholine receptors | |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |
| Highly sodium permeable acetylcholine nicotinic receptors | |
| Voltage gated Potassium channels | |
| Xenobiotics |
