UCSF

LXR-beta, Human (442 Compounds)

Swissprot:
NR1H2_HUMAN
Stitch:
NR1H2_HUMAN
UniProt:
P55055
ChEMBL:
CHEMBL4093
Reactome:
REACT_15525
PDB:
1P8D (DOCK)
1PQ6 (DOCK)
1PQ9 (DOCK)
1PQC (DOCK)
1UPV (DOCK)
1UPW (DOCK)
3KFC (DOCK)
3L0E (DOCK)
NR1H2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 442 4 4 2
Binding ≤ 1μM 398 4 3 2
Functional ≤ 10μM 336 2 4 1

Reactome Network (1)

Reactome ID Description Species
REACT_15525 Nuclear Receptor transcription pathway Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 1
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 19
PPARD_HUMAN Q03181 CHEMBL3979 Peroxisome Proliferator-activated Receptor Delta, Human 21
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 18
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NR1H3_HUMAN Q13133 CHEMBL2808 LXR-alpha, Human 485 14 11 3
NR1H4_HUMAN Q96RI1 CHEMBL2047 Bile Acid Receptor FXR, Human 372 7 7 3

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
NR1H2-1-E LXR-beta (cluster #1 Of 3), Eukaryotic 378 2 3 2
NR1H2-2-E LXR-beta (cluster #2 Of 3), Eukaryotic 67 3 0 0
NR1H2-3-E LXR-beta (cluster #3 Of 3), Eukaryotic 1 0 1 0
Uniprot Swissprot Chembl Description Number Shared
NR1H3_HUMAN Q13133 CHEMBL2808 LXR-alpha, Human 471
Z80548 Z80548 CHEMBL614245 THP-1 (Acute Monocytic Leukemia Cells) 33
PPARD_HUMAN Q03181 CHEMBL3979 Peroxisome Proliferator-activated Receptor Delta, Human 21
PPARA_HUMAN Q07869 CHEMBL239 Peroxisome Proliferator-activated Receptor Alpha, Human 19
PPARG_HUMAN P37231 CHEMBL235 Peroxisome Proliferator-activated Receptor Gamma, Human 17
Z81020 Z81020 CHEMBL395 HepG2 (Hepatoblastoma Cells) 14
Z81244 Z81244 CHEMBL614123 J774 (Macrophage Cells) 5
NR1I2_HUMAN O75469 CHEMBL3401 Pregnane X Receptor, Human 4
Z80178 Z80178 CHEMBL614040 J774.A1 (Macrophage Cells) 4
Z50594 Z50594 CHEMBL375 Mus Musculus 3
GCR_HUMAN P04150 CHEMBL2034 Glucocorticoid Receptor, Human 2
Z80169 Z80169 CHEMBL614039 Huh-7 (Hepatocellular Carcinoma) 2
ANDR_HUMAN P10275 CHEMBL1871 Androgen Receptor, Human 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1

Most Common Rings