UCSF

Transforming Protein P21/H-Ras-1, Human (40 Compounds)

Swissprot:
RASH_HUMAN
Stitch:
RASH_HUMAN
UniProt:
P01112
ChEMBL:
CHEMBL2167
Reactome:
REACT_118778
REACT_147814
REACT_17025
REACT_121096
REACT_228085
REACT_163701
REACT_21247
REACT_12606
REACT_115854
REACT_23891
REACT_962
REACT_18334
REACT_12065
REACT_2077
REACT_614
REACT_20546
REACT_21374
REACT_661
REACT_12579
REACT_115993
REACT_116005
REACT_115852
REACT_121398
REACT_111040
REACT_12033
REACT_524
REACT_12621
REACT_228024
PDB:
121P (DOCK)
1AA9 (DOCK)
1AGP (DOCK)
1BKD (DOCK)
1CLU (DOCK)
1CRP (DOCK)
1CRQ (DOCK)
1CRR (DOCK)
1CTQ (DOCK)
1GNP (DOCK)
1GNQ (DOCK)
1GNR (DOCK)
1HE8 (DOCK)
1IAQ (DOCK)
1IOZ (DOCK)
1JAH (DOCK)
1JAI (DOCK)
1K8R (DOCK)
1LF0 (DOCK)
1LF5 (DOCK)
1LFD (DOCK)
1NVU (DOCK)
1NVV (DOCK)
1NVW (DOCK)
1NVX (DOCK)
1P2S (DOCK)
1P2T (DOCK)
1P2U (DOCK)
1P2V (DOCK)
1PLJ (DOCK)
1PLK (DOCK)
1PLL (DOCK)
1Q21 (DOCK)
1QRA (DOCK)
1RVD (DOCK)
1WQ1 (DOCK)
1XCM (DOCK)
1XD2 (DOCK)
1XJ0 (DOCK)
1ZVQ (DOCK)
1ZW6 (DOCK)
221P (DOCK)
2C5L (DOCK)
2CE2 (DOCK)
2CL0 (DOCK)
2CL6 (DOCK)
2CL7 (DOCK)
2CLC (DOCK)
2CLD (DOCK)
2EVW (DOCK)
2GDP (DOCK)
2LCF (DOCK)
2Q21 (DOCK)
2QUZ (DOCK)
2RGA (DOCK)
2RGB (DOCK)
2RGC (DOCK)
2RGD (DOCK)
2RGE (DOCK)
2RGG (DOCK)
2UZI (DOCK)
2VH5 (DOCK)
2X1V (DOCK)
3DDC (DOCK)
3I3S (DOCK)
3K8Y (DOCK)
3K9L (DOCK)
3K9N (DOCK)
3KKM (DOCK)
3KKN (DOCK)
3KUD (DOCK)
3L8Y (DOCK)
3L8Z (DOCK)
3LBH (DOCK)
3LBI (DOCK)
3LBN (DOCK)
3LO5 (DOCK)
3OIU (DOCK)
3OIV (DOCK)
3OIW (DOCK)
3RRY (DOCK)
3RRZ (DOCK)
3RS0 (DOCK)
3RS2 (DOCK)
3RS3 (DOCK)
3RS4 (DOCK)
3RS5 (DOCK)
3RS7 (DOCK)
3RSL (DOCK)
3RSO (DOCK)
3TGP (DOCK)
421P (DOCK)
4Q21 (DOCK)
521P (DOCK)
5P21 (DOCK)
621P (DOCK)
6Q21 (DOCK)
721P (DOCK)
821P (DOCK)
HRAS

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 40 1 1 1
Binding ≤ 1μM 18 1 1 1
Functional ≤ 10μM 16 0 0 1

Reactome Network (28)

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
FNTA_RAT Q04631 CHEMBL4432 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Rat 7
FNTB_RAT Q02293 CHEMBL4890 Protein Farnesyltransferase Beta Subunit, Rat 7
Q5EI73_PLAFA Q5EI73 CHEMBL4737 Protein Farnesyltransferase Alpha Subunit, Plafa 7
Q5EI74_PLAFA Q5EI74 CHEMBL1741264 Protein Farnesyltransferase Beta Subunit, Plafa 7
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 3
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 3
FNTA_HUMAN P49354 CHEMBL271 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human 3
FNTB_HUMAN P49356 CHEMBL272 Protein Farnesyltransferase Beta Subunit, Human 3
RAP1A_HUMAN P62834 CHEMBL1255139 Ras-related Protein Rap-1A, Human 2
Z80951 Z80951 CHEMBL614822 NIH3T3 (Fibroblasts) 2
FNTA_MOUSE Q61239 CHEMBL2153 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Mouse 1
FNTB_MOUSE Q8K2I1 CHEMBL2631 Protein Farnesyltransferase Beta Subunit, Mouse 1
TOP1_HUMAN P11387 CHEMBL1781 DNA Topoisomerase I, Human 1
Z80106 Z80106 CHEMBL614563 COS-1 (Kidney Cells) 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z80928 Z80928 CHEMBL394 HCT-116 (Colon Carcinoma Cells) 1
Z81285 Z81285 CHEMBL615000 NIH-H Cell Line 1
Z81286 Z81286 CHEMBL615001 NIH-K Cell Line 1