ZINC 12

User Information

Not Authenticated — sign in

Active cart: Temporary Cart (0 items)

Navigation

About
- ZINC
- BCIRC
- Irwin Lab
- Shoichet Lab
- UCSF
- Acknowledgements
- Facts
- Usage
Search
- By:
- Text
- Structure
- Properties
- Catalogs
- ZINC
- Targets
- Rings
- Combination
Subsets
- By:
- Catalog
- Property
- Target
- Ring
- Cart
Help
- Introduction
- FAQ
- Scripting/API
- Quick Search
- Problems
- Filtering
- History
Social
- ZINC Fans
- Decoy Club
- DOCK Fans
- Facebook
- Twitter
- Blog
- Linkedin
Quick Search ZINC ID or SMILES

Results
Query Details

Page Size:

Format: Representations: Purchasability:

ZINC Item

Suppliers, Protomers, & Similar Substances

49917631

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2,6-difluoro-N-[3-[3-[2-[4-(4-pyridylmethyl)anilino]pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-2-yl]pheny 2,6-difluoro-N-[3-[3-[2-[4-(4-py…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.93	18.6	-29.85	2	8	0	97	609.64	8	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	6.93	19.06	-58.61	3	8	1	98	610.648	8	↓ MOL2 SDF SMILES Flexibase

49917793

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2,3,6-trifluoro-N-[3-[3-[2-(3-fluoroanilino)pyrimidin-4-yl]pyrazolo[1,5-a]pyridin-2-yl]phenyl]benzam 2,3,6-trifluoro-N-[3-[3-[2-(3-fl…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.51	16.02	-25.86	2	7	0	84	554.507	6	↓ MOL2 SDF SMILES Flexibase

33817408

Analogs

34392506
1553423
596607

Draw Identity 99% 90% 80% 70%

Popular Name: 3-[2-(butylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyridin-7-am 3-[2-(butylamino)pyrimidin-4-yl]…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.90	11.28	-11.93	2	8	0	80	489.599	10	↓ MOL2 SDF SMILES Flexibase

71524194

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2R)-1-(pyrazolo[1,5-a]pyridine-3-carbonyl)-4-pyrimidin-2-yl-piperazine-2-carboxylic (2R)-1-(pyrazolo[1,5-a]pyridine-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	-1.53	10.27	-73.71	0	9	-1	107	351.346	3	↓ MOL2 SDF SMILES Flexibase

71524199

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2S)-1-(pyrazolo[1,5-a]pyridine-3-carbonyl)-4-pyrimidin-2-yl-piperazine-2-carboxylic (2S)-1-(pyrazolo[1,5-a]pyridine-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	-1.53	10.38	-73.04	0	9	-1	107	351.346	3	↓ MOL2 SDF SMILES Flexibase

71575191

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-4-benzyl-3-ethyl-1-(pyrazolo[1,5-a]pyridine-3-carbonyl)-1,4-diazepan-5-one (3R)-4-benzyl-3-ethyl-1-(pyrazol…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.14	10.55	-14.43	0	6	0	58	376.46	4	↓ MOL2 SDF SMILES Flexibase

71575192

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-4-benzyl-3-ethyl-1-(pyrazolo[1,5-a]pyridine-3-carbonyl)-1,4-diazepan-5-one (3S)-4-benzyl-3-ethyl-1-(pyrazol…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.14	10.53	-14.51	0	6	0	58	376.46	4	↓ MOL2 SDF SMILES Flexibase

53314133

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-cyclohexylpyrazolo[1,5-a]pyridine-7-carboxamide 2-cyclohexylpyrazolo[1,5-a]pyrid…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.29	5.12	-8.44	2	4	0	60	243.31	2	↓ MOL2 SDF SMILES Flexibase

71589672

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-(pyrazolo[1,5-a]pyridin-3-ylmethyl)-4-(3,3,3-trifluoropropyl)pyrimidin-2-amine N-(pyrazolo[1,5-a]pyridin-3-ylme…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.11	9.22	-10.65	1	5	0	55	321.306	6	↓ MOL2 SDF SMILES Flexibase

21533706

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-thiazol-2-ylpyrazolo[1,5-a]pyridine-2-carboxamide N-thiazol-2-ylpyrazolo[1,5-a]pyr…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.68	4.82	-15.98	1	5	0	59	244.279	2	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.75	3.66	-53.92	0	5	-1	66	243.271	2	↓ MOL2 SDF SMILES Flexibase

21533708

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(1S)-2-(2-furyl)-1-methyl-ethyl]pyrazolo[1,5-a]pyridine-2-carboxamide N-[(1S)-2-(2-furyl)-1-methyl-eth…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.32	6.08	-14.46	1	5	0	60	269.304	4	↓ MOL2 SDF SMILES Flexibase

21533711

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[(1R)-2-(2-furyl)-1-methyl-ethyl]pyrazolo[1,5-a]pyridine-2-carboxamide N-[(1R)-2-(2-furyl)-1-methyl-eth…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.32	6.12	-14.92	1	5	0	60	269.304	4	↓ MOL2 SDF SMILES Flexibase

21533714

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N-[2-(benzyl-methyl-amino)ethyl]pyrazolo[1,5-a]pyridine-2-carboxamide N-[2-(benzyl-methyl-amino)ethyl]…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.36	8.27	-47.3	2	5	1	51	309.393	6	↓ MOL2 SDF SMILES Flexibase

62319399

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 6-(Hydroxymethyl)pyrazolo[1,5-a]pyridine-3-carboxylic acid 6-(Hydroxymethyl)pyrazolo[1,5-a]…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.29	2.28	-57.13	1	5	-1	78	191.166	2	↓ MOL2 SDF SMILES Flexibase

26143371

Analogs

600528

Draw Identity 99% 90% 80% 70%

Popular Name: 2-[2-[6-oxo-3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-1-yl]-1-cyclopentenyl]acetic 2-[2-[6-oxo-3-(2-phenylpyrazolo[…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
AA1R-2-E	Adenosine A1 Receptor (cluster #2 Of 4), Eukaryotic	Eukaryotes	11	0.36	Binding ≤ 10μM
AA2AR-1-E	Adenosine A2a Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	840	0.27	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
AA1R_RAT	P25099	Adenosine A1 Receptor, Rat	11	0.36	Binding ≤ 1μM
AA2AR_RAT	P30543	Adenosine A2a Receptor, Rat	840	0.27	Binding ≤ 1μM
AA1R_RAT	P25099	Adenosine A1 Receptor, Rat	11	0.36	Binding ≤ 10μM
AA2AR_RAT	P30543	Adenosine A2a Receptor, Rat	840	0.27	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.35	12.18	-65.51	0	7	-1	92	411.441	5	↓ MOL2 SDF SMILES Flexibase

59816163

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 7-amino-2-tert-butyl-5-methyl-6-phenyl-pyrazolo[1,5-a]pyridine-4-carbonitrile 7-amino-2-tert-butyl-5-methyl-6-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.86	10.02	-6.89	2	4	0	67	304.397	2	↓ MOL2 SDF SMILES Flexibase

59816460

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ethyl ethyl

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.27	9.58	-13.09	2	6	0	93	334.379	4	↓ MOL2 SDF SMILES Flexibase

59816690

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-tert-butyl-3-chloro-7-[(2R)-2-(dimethylamino)pyrrolidin-1-yl]-5-methyl-6-phenyl-pyrazolo[1,5-a]pyr 2-tert-butyl-3-chloro-7-[(2R)-2-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.49	14.4	-7	0	5	0	48	436.003	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	6.49	14.51	-40.49	1	5	1	49	437.011	4	↓ MOL2 SDF SMILES Flexibase

59816694

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-tert-butyl-3-chloro-7-[(2S)-2-(dimethylamino)pyrrolidin-1-yl]-5-methyl-6-phenyl-pyrazolo[1,5-a]pyr 2-tert-butyl-3-chloro-7-[(2S)-2-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	6.49	13.06	-6.84	0	5	0	48	436.003	4	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	6.49	15.98	-38.57	1	5	1	49	437.011	4	↓ MOL2 SDF SMILES Flexibase

59816793

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ethyl ethyl

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.46	11.01	-10.7	0	5	0	67	353.809	4	↓ MOL2 SDF SMILES Flexibase

59817012

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ethyl ethyl

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.29	14.06	-12.26	0	7	0	74	431.54	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.29	13.92	-44.99	1	7	1	75	432.548	6	↓ MOL2 SDF SMILES Flexibase

59817015

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: ethyl ethyl

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	4.29	12.39	-12.05	0	7	0	74	431.54	6	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.29	15.34	-44.09	1	7	1	75	432.548	6	↓ MOL2 SDF SMILES Flexibase

68890468

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-methylsulfanyl-N-(pyrazolo[1,5-a]pyridin-3-ylmethyl)ethanamine 2-methylsulfanyl-N-(pyrazolo[1,5…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.51	6.27	-44.17	2	3	1	34	222.337	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	1.51	4.91	-7.49	1	3	0	29	221.329	5	↓ MOL2 SDF SMILES Flexibase

52537243

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-oxo-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2,3-dihydro-4-pyridazinecarboxylic acid 3-oxo-6-(2-phenylpyrazolo[1,5-a]…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.86	5.66	-52.37	1	7	-1	103	331.311	3	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.86	6.67	-140.21	0	7	-2	106	330.303	3	↓ MOL2 SDF SMILES Flexibase

52537246

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-oxo-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2,3-dihydro-4-pyridazinecarboxamide 3-oxo-6-(2-phenylpyrazolo[1,5-a]…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.11	3.37	-65.12	2	7	-1	109	330.327	3	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	1.65	3.99	-13.23	3	7	0	106	331.335	3	↓ MOL2 SDF SMILES Flexibase

52537248

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-chloro-6-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-4-pyridazinecarbonitrile 3-chloro-6-(2-phenylpyrazolo[1,5…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.94	9.2	-12.46	0	5	0	67	331.766	2	↓ MOL2 SDF SMILES Flexibase

69143304

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3R)-1,1-dioxo-N-(pyrazolo[1,5-a]pyridin-3-ylmethyl)thian-3-amine (3R)-1,1-dioxo-N-(pyrazolo[1,5-a…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.77	3.49	-59.63	2	5	1	68	280.373	3	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	0.77	2.3	-15.84	1	5	0	63	279.365	3	↓ MOL2 SDF SMILES Flexibase

69143306

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3S)-1,1-dioxo-N-(pyrazolo[1,5-a]pyridin-3-ylmethyl)thian-3-amine (3S)-1,1-dioxo-N-(pyrazolo[1,5-a…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.77	3.48	-60.79	2	5	1	68	280.373	3	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	0.77	2.3	-17.7	1	5	0	63	279.365	3	↓ MOL2 SDF SMILES Flexibase

64539648

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: [4-fluoro-4-[[(5-methyl-2-pyridyl)methylamino]methyl]-1-piperidyl]-pyrazolo[1,5-a]pyridin-2-yl-metha [4-fluoro-4-[[(5-methyl-2-pyridy…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
5HT1A-1-E	Serotonin 1a (5-HT1a) Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	93	0.35	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	93	0.35	Binding ≤ 1μM
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	93	0.35	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.40	9.28	-51.65	2	6	1	67	382.463	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.40	7.92	-15.55	1	6	0	63	381.455	5	↓ MOL2 SDF SMILES Flexibase

64548836

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: [4-fluoro-4-[[(5-methyl-2-pyridyl)methylamino]methyl]-1-piperidyl]-pyrazolo[1,5-a]pyridin-3-yl-metha [4-fluoro-4-[[(5-methyl-2-pyridy…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
5HT1A-1-E	Serotonin 1a (5-HT1a) Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	310	0.33	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	310	0.33	Binding ≤ 1μM
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	310	0.33	Binding ≤ 10μM

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.62	8.79	-52.33	2	6	1	67	382.463	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	1.62	7.57	-14.81	1	6	0	63	381.455	5	↓ MOL2 SDF SMILES Flexibase

65314706

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: N,N-dimethyl-4-[3-(morpholine-4-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]piperidine-1-sulfonamide N,N-dimethyl-4-[3-(morpholine-4-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.44	4.45	-17.63	0	9	0	87	421.523	4	↓ MOL2 SDF SMILES Flexibase

65314707

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: morpholino-[5-(1-morpholinosulfonyl-4-piperidyl)pyrazolo[1,5-a]pyridin-3-yl]methanone morpholino-[5-(1-morpholinosulfo…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	0.29	4.01	-18.52	0	10	0	97	463.56	4	↓ MOL2 SDF SMILES Flexibase

65315601

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: [3-(dimethylamino)phenyl]-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]met [3-(dimethylamino)phenyl]-[4-[3-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.26	11.12	-19.18	0	7	0	61	445.567	4	↓ MOL2 SDF SMILES Flexibase

65315602

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2-bromophenyl)-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]methanone (2-bromophenyl)-[4-[3-(pyrrolidi…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.94	11.34	-18.9	0	6	0	58	481.394	3	↓ MOL2 SDF SMILES Flexibase

65315603

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (3-chlorophenyl)-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]methanone (3-chlorophenyl)-[4-[3-(pyrrolid…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.84	11.23	-18.94	0	6	0	58	436.943	3	↓ MOL2 SDF SMILES Flexibase

65315604

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: cyclobutyl-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]methanone cyclobutyl-[4-[3-(pyrrolidine-1-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.99	10.01	-18.26	0	6	0	58	380.492	3	↓ MOL2 SDF SMILES Flexibase

65315605

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-cyclopentyl-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]propan-1-one 3-cyclopentyl-1-[4-[3-(pyrrolidi…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.27	12.16	-18.31	0	6	0	58	422.573	5	↓ MOL2 SDF SMILES Flexibase

65315606

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: cyclopropyl-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]methanone cyclopropyl-[4-[3-(pyrrolidine-1…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	1.81	9.51	-18.31	0	6	0	58	366.465	3	↓ MOL2 SDF SMILES Flexibase

65315609

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3-methoxyphenyl)-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]ethanon 2-(3-methoxyphenyl)-1-[4-[3-(pyr…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.78	11.05	-21.58	0	7	0	67	446.551	5	↓ MOL2 SDF SMILES Flexibase

65315611

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-(4-methoxyphenyl)-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]propan- 3-(4-methoxyphenyl)-1-[4-[3-(pyr…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.32	11.85	-19.73	0	7	0	67	460.578	6	↓ MOL2 SDF SMILES Flexibase

65315616

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (4-bromophenyl)-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]methanone (4-bromophenyl)-[4-[3-(pyrrolidi…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.99	11.35	-17.42	0	6	0	58	481.394	3	↓ MOL2 SDF SMILES Flexibase

65315619

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 3-methyl-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]butan-1-one 3-methyl-1-[4-[3-(pyrrolidine-1-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.60	10.14	-17.75	0	6	0	58	382.508	4	↓ MOL2 SDF SMILES Flexibase

65315622

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(4-chlorophenoxy)-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]ethanon 2-(4-chlorophenoxy)-1-[4-[3-(pyr…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.30	12.17	-22.38	0	7	0	67	466.969	5	↓ MOL2 SDF SMILES Flexibase

65315624

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2-chloro-6-fluoro-phenyl)-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]me (2-chloro-6-fluoro-phenyl)-[4-[3…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.93	11.36	-20.11	0	6	0	58	454.933	3	↓ MOL2 SDF SMILES Flexibase

65315626

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-(3-fluorophenyl)-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]ethanone 2-(3-fluorophenyl)-1-[4-[3-(pyrr…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.89	11.82	-20.98	0	6	0	58	434.515	4	↓ MOL2 SDF SMILES Flexibase

65315627

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: (2,3-dimethoxyphenyl)-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]methano (2,3-dimethoxyphenyl)-[4-[3-(pyr…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.55	10.36	-23.53	0	8	0	76	462.55	5	↓ MOL2 SDF SMILES Flexibase

65315629

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2,2-dimethyl-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]propan-1-one 2,2-dimethyl-1-[4-[3-(pyrrolidin…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.64	9.42	-18.26	0	6	0	58	382.508	3	↓ MOL2 SDF SMILES Flexibase

65315634

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]butan-1-one 1-[4-[3-(pyrrolidine-1-carbonyl)…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.38	9.54	-18.33	0	6	0	58	368.481	4	↓ MOL2 SDF SMILES Flexibase

65315635

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-methyl-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]propan-1-one 2-methyl-1-[4-[3-(pyrrolidine-1-…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.06	9.28	-18.43	0	6	0	58	368.481	3	↓ MOL2 SDF SMILES Flexibase

65315638

Analogs

Draw Identity 99% 90% 80% 70%

Popular Name: 2-phenoxy-1-[4-[3-(pyrrolidine-1-carbonyl)pyrazolo[1,5-a]pyridin-5-yl]-1-piperidyl]ethanone 2-phenoxy-1-[4-[3-(pyrrolidine-1…

Find On: PubMed — Wikipedia — Google

Activity (Go SEA)

Physical Representations

Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.62	11.65	-22.73	0	7	0	67	432.524	5	↓ MOL2 SDF SMILES Flexibase

Parameters Provided:

ring.id = 9021
filter.purchasability = annotated
page.format = targets
page.num = 1

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN hasring AS hr ON ci.sub_id_fk=hr.sub_id_fk INNER JOIN rings AS r ON hr.rings_fk=r.rings_id  WHERE r.rings_id = 9021 AND c.free = 1 AND c.purchasable = 0    LIMIT 50

Permalink

//zinc12.docking.org/results/combination?ring.id=9021&filter.purchasability=annotated

Embed Link to Results

<div id="zinc-link"></div>
<script type="text/javascript" src="//zinc12.docking.org/js/embed.js"></script>
<script type="text/javascript">
    window.zinc.embed('zinc-link', {
        "ring.id": "9021"        

    });
</script>

ZINC 12

User Information

Navigation

About

Search

Subsets

Help

Social

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations

Analogs

Activity (Go SEA)

Physical Representations