| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 26th, 2005 | 17 | Yes |
Popular Name: Ribavirin Ribavirin
Find On: PubMed — Wikipedia — Google
CAS Numbers: 15956-28-2 , 36791-04-5 , [36791-04-5]
1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1H-1,2,4-Triazole-3-carboxamide, 1-.beta.-D-ribofuranosyl-
1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-
RBV;Ribavirina [INN-Spanish];Ribavirine [INN-French];Ribavirinum [INN-Latin]
Rebetol, Ribasphere, Vilona, Virazole
Ribavirin, Antibiotic for Culture Media Use Only
ribavirin; ribavirina; ribavirine; ribavirinum
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.77 | -8.13 | -17.41 | 5 | 9 | 0 | 144 | 244.207 | 3 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| MP | 165 - 167 | Enamine Building Blocks |
| MP | 165...167 | Enamine Building Blocks |
| MP | 176 | TCI |
| ALOGPS_SOLUBILITY | 3.32e+01 g/l | DrugBank-approved |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Purity | 95% | Fluorochem |
| Purity | 95+% | Matrix Scientific |
| Target | Antifection | Selleck Chemicals |
| Therapy | antiviral | SMDC Iconix |
| biological_use | Antiviral agent | IBScreen Bioactives ZereneX Building Blocks |
| UniProt Database Links | IMDH1_HUMAN; IMDH2_HUMAN; POLG_POL1M; S28A3_EPTST; S28A3_HUMAN; S28A3_MOUSE; S28A3_RAT | ChEBI |
| biological_use | In combination with BDQ70-A , used for the treatment of malignant melanoma, Kaposi's sarcoma, warts, hairy cell leukaemia, hepatits B and C and non-Hodgkin's lymphoma | IBScreen Bioactives |
| mechanism | Inhibitor of viral RNA guanylyl transferase and (guanine-7N-)-methyl transferase enzymes | ZereneX Building Blocks |
| Warnings | IRRITANT | Matrix Scientific |
| Target | Others | Selleck Chemicals |
| biological_use | Usually administered as an aerosol. | IBScreen Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z100497-1-O | Bovine Viral Diarrhea Virus (cluster #1 Of 3), Other | Other | 7000 | 0.42 | Functional ≤ 10μM |
| Z100811-1-O | Influenza A Virus (H5N1) (cluster #1 Of 1), Other | Other | 9400 | 0.41 | Functional ≤ 10μM |
| Z101822-1-O | H3N2 Subtype (cluster #1 Of 2), Other | Other | 9000 | 0.42 | Functional ≤ 10μM |
| Z50142-1-O | Influenza A Virus (A/PR/8/34(H1N1)) (cluster #1 Of 2), Other | Other | 9700 | 0.41 | Functional ≤ 10μM |
| Z50523-1-O | Influenza B Virus (cluster #1 Of 1), Other | Other | 9000 | 0.42 | Functional ≤ 10μM |
| Z50525-1-O | Tacaribe Virus (cluster #1 Of 1), Other | Other | 10000 | 0.41 | Functional ≤ 10μM |
| Z50594-1-O | Mus Musculus (cluster #1 Of 9), Other | Other | 8300 | 0.42 | Functional ≤ 10μM |
| Z50602-2-O | Human Herpesvirus 1 (cluster #2 Of 5), Other | Other | 10000 | 0.41 | Functional ≤ 10μM |
| Z50641-1-O | West Nile Virus (cluster #1 Of 2), Other | Other | 1100 | 0.49 | Functional ≤ 10μM |
| Z50651-1-O | Vesicular Stomatitis Virus (cluster #1 Of 2), Other | Other | 10000 | 0.41 | Functional ≤ 10μM |
| Z50652-1-O | Influenza A Virus (cluster #1 Of 4), Other | Other | 9800 | 0.41 | Functional ≤ 10μM |
| Z50678-2-O | Respiratory Syncytial Virus (cluster #2 Of 2), Other | Other | 7000 | 0.42 | Functional ≤ 10μM |
| Z80040-1-O | BHK-21 (Kidney Cells) (cluster #1 Of 1), Other | Other | 1100 | 0.49 | Functional ≤ 10μM |
| Z80249-1-O | MDCK (Kidney Cells) (cluster #1 Of 2), Other | Other | 4900 | 0.44 | Functional ≤ 10μM |
| Z80285-1-O | MOLT-4 (Acute T-lymphoblastic Leukemia Cells) (cluster #1 Of 4), Other | Other | 5700 | 0.43 | Functional ≤ 10μM |
| Z80823-1-O | E6SM (Embryonic Skin-muscle Fibroblast Cells) (cluster #1 Of 1), Other | Other | 5 | 0.68 | Functional ≤ 10μM |
| Z81247-1-O | HeLa (Cervical Adenocarcinoma Cells) (cluster #1 Of 9), Other | Other | 1500 | 0.48 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z80040 | Z80040 | BHK-21 (Kidney Cells) | 1100 | 0.49 | Functional ≤ 10μM |
| Z100497 | Z100497 | Bovine Viral Diarrhea Virus | 4620 | 0.44 | Functional ≤ 10μM |
| Z80823 | Z80823 | E6SM (Embryonic Skin-muscle Fibroblast Cells) | 5 | 0.68 | Functional ≤ 10μM |
| Z101822 | Z101822 | H3N2 Subtype | 8100 | 0.42 | Functional ≤ 10μM |
| Z81247 | Z81247 | HeLa (Cervical Adenocarcinoma Cells) | 1500 | 0.48 | Functional ≤ 10μM |
| Z50602 | Z50602 | Human Herpesvirus 1 | 10000 | 0.41 | Functional ≤ 10μM |
| Z50652 | Z50652 | Influenza A Virus | 4900 | 0.44 | Functional ≤ 10μM |
| Z50142 | Z50142 | Influenza A Virus (A/PR/8/34(H1N1)) | 9000 | 0.42 | Functional ≤ 10μM |
| Z100811 | Z100811 | Influenza A Virus (H5N1) | 4300 | 0.44 | Functional ≤ 10μM |
| Z50523 | Z50523 | Influenza B Virus | 4000 | 0.44 | Functional ≤ 10μM |
| Z80249 | Z80249 | MDCK (Kidney Cells) | 3700 | 0.45 | Functional ≤ 10μM |
| Z80285 | Z80285 | MOLT-4 (Acute T-lymphoblastic Leukemia Cells) | 5700 | 0.43 | Functional ≤ 10μM |
| Z50594 | Z50594 | Mus Musculus | 8300 | 0.42 | Functional ≤ 10μM |
| Z50678 | Z50678 | Respiratory Syncytial Virus | 10000 | 0.41 | Functional ≤ 10μM |
| Z50525 | Z50525 | Tacaribe Virus | 10000 | 0.41 | Functional ≤ 10μM |
| Z50651 | Z50651 | Vesicular Stomatitis Virus | 10000 | 0.41 | Functional ≤ 10μM |
| Z50641 | Z50641 | West Nile Virus | 1100 | 0.49 | Functional ≤ 10μM |
