| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 25th, 2008 | 15 | Yes |
Popular Name: (2S)-2-amino-3-(5-chloro-2,4-dioxo-pyrimidin-1-yl)propanoic (2S)-2-amino-3-(5-chloro-2,4-dio…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -3.35 | -0.77 | -39.5 | 4 | 7 | 0 | 123 | 233.611 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-2-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 65 | 0.67 | Binding ≤ 10μM |
| GRIA2-4-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 53 | 0.68 | Binding ≤ 10μM |
| GRIA3-4-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 451 | 0.59 | Binding ≤ 10μM |
| GRIA4-4-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #4 Of 5), Eukaryotic | Eukaryotes | 451 | 0.59 | Binding ≤ 10μM |
| GRIK1-2-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 47 | 0.68 | Binding ≤ 10μM |
| GRIK5-1-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 57 | 0.68 | Binding ≤ 10μM |
| GRIA2-2-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 2110 | 0.53 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 47 | 0.68 | Binding ≤ 1μM |
| GRIK5_HUMAN | Q16478 | Glutamate Receptor Ionotropic Kainate 5, Human | 57.1 | 0.68 | Binding ≤ 1μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 65 | 0.67 | Binding ≤ 1μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 37 | 0.69 | Binding ≤ 1μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 53.1 | 0.68 | Binding ≤ 1μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 45 | 0.69 | Binding ≤ 1μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 451 | 0.59 | Binding ≤ 1μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 451 | 0.59 | Binding ≤ 1μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 561 | 0.58 | Binding ≤ 1μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 47 | 0.68 | Binding ≤ 10μM |
| GRIK5_HUMAN | Q16478 | Glutamate Receptor Ionotropic Kainate 5, Human | 57.1 | 0.68 | Binding ≤ 10μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 65 | 0.67 | Binding ≤ 10μM |
| GRIA1_RAT | P19490 | Glutamate Receptor Ionotropic, AMPA 1, Rat | 37 | 0.69 | Binding ≤ 10μM |
| GRIA2_HUMAN | P42262 | Glutamate Receptor Ionotropic, AMPA 2, Human | 53.1 | 0.68 | Binding ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 45 | 0.69 | Binding ≤ 10μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 451 | 0.59 | Binding ≤ 10μM |
| GRIA4_HUMAN | P48058 | Glutamate Receptor Ionotropic, AMPA 4, Human | 451 | 0.59 | Binding ≤ 10μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 561 | 0.58 | Binding ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 2110 | 0.53 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Trafficking of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
No pre-computed analogs available. Try a structural similarity search.