| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 27th, 2004 | 11 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.69 | 2.22 | -74.96 | 3 | 5 | -1 | 108 | 158.133 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 380 | 0.82 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 454 | 0.81 | Binding ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 490 | 0.80 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 440 | 0.81 | Functional ≤ 10μM |
| GRM4-1-E | Metabotropic Glutamate Receptor 4 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 4000 | 0.69 | Functional ≤ 10μM |
| GRM5-5-E | Metabotropic Glutamate Receptor 5 (cluster #5 Of 5), Eukaryotic | Eukaryotes | 3100 | 0.70 | Functional ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 600 | 0.79 | Functional ≤ 10μM |
| GRM8-1-E | Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 400 | 0.81 | Functional ≤ 10μM |
| Z50597-7-O | Rattus Norvegicus (cluster #7 Of 12), Other | Other | 700 | 0.78 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 380 | 0.82 | Binding ≤ 1μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 454 | 0.81 | Binding ≤ 1μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 454 | 0.81 | Binding ≤ 1μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 380 | 0.82 | Binding ≤ 10μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 454 | 0.81 | Binding ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 454 | 0.81 | Binding ≤ 10μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 300 | 0.83 | Functional ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 490 | 0.80 | Functional ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 440 | 0.81 | Functional ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 600 | 0.79 | Functional ≤ 10μM |
| GRM4_RAT | P31423 | Metabotropic Glutamate Receptor 4, Rat | 4000 | 0.69 | Functional ≤ 10μM |
| GRM5_HUMAN | P41594 | Metabotropic Glutamate Receptor 5, Human | 3100 | 0.70 | Functional ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 5800 | 0.67 | Functional ≤ 10μM |
| GRM6_RAT | P35349 | Metabotropic Glutamate Receptor 6, Rat | 600 | 0.79 | Functional ≤ 10μM |
| GRM8_HUMAN | O00222 | Metabotropic Glutamate Receptor 8, Human | 3400 | 0.70 | Functional ≤ 10μM |
| GRM8_RAT | P70579 | Metabotropic Glutamate Receptor 8, Rat | 400 | 0.81 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 1100 | 0.76 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events |
