| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 31st, 2005 | 12 | Yes |
Popular Name: LS-58513 LS-58513
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.08 | -2.64 | -74.57 | 3 | 5 | -1 | 107 | 172.16 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 8 | 0.94 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 38 | 0.87 | Functional ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1198 | 0.69 | Functional ≤ 10μM |
| GRM8-1-E | Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1320 | 0.69 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 8 | 0.94 | Functional ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 38 | 0.87 | Functional ≤ 10μM |
| GRM6_RAT | P35349 | Metabotropic Glutamate Receptor 6, Rat | 1198 | 0.69 | Functional ≤ 10μM |
| GRM8_RAT | P70579 | Metabotropic Glutamate Receptor 8, Rat | 1320 | 0.69 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events |
