| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 27th, 2004 | 11 | Yes |
Popular Name: L-CCG-I L-CCG-I
Find On: PubMed — Wikipedia — Google
CAS Numbers: 117857-93-9 , 117857-95-1
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.69 | 2.3 | -80.67 | 3 | 5 | -1 | 108 | 158.133 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-3-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 600 | 0.79 | Binding ≤ 10μM |
| GRIA2-3-E | Glutamate Receptor Ionotropic, AMPA 2 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 600 | 0.79 | Binding ≤ 10μM |
| GRIA3-3-E | Glutamate Receptor Ionotropic, AMPA 3 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 600 | 0.79 | Binding ≤ 10μM |
| GRIA4-3-E | Glutamate Receptor Ionotropic, AMPA 4 (cluster #3 Of 5), Eukaryotic | Eukaryotes | 600 | 0.79 | Binding ≤ 10μM |
| GRIK1-3-E | Glutamate Receptor Ionotropic Kainate 1 (cluster #3 Of 3), Eukaryotic | Eukaryotes | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK2-2-E | Glutamate Receptor Ionotropic Kainate 2 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK3-2-E | Glutamate Receptor Ionotropic Kainate 3 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK4-2-E | Glutamate Receptor Ionotropic Kainate 4 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK5-2-E | Glutamate Receptor Ionotropic Kainate 5 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1600 | 0.74 | Binding ≤ 10μM |
| Z104302-3-O | Glutamate NMDA Receptor (cluster #3 Of 7), Other | Other | 5 | 1.06 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z104302 | Z104302 | Glutamate NMDA Receptor | 100 | 0.89 | Binding ≤ 1μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 600 | 0.79 | Binding ≤ 1μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 600 | 0.79 | Binding ≤ 1μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 600 | 0.79 | Binding ≤ 1μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 600 | 0.79 | Binding ≤ 1μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 100 | 0.89 | Binding ≤ 10μM |
| GRIK1_RAT | P22756 | Glutamate Receptor Ionotropic Kainate 1, Rat | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK2_RAT | P42260 | Glutamate Receptor Ionotropic Kainate 2, Rat | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK3_RAT | P42264 | Glutamate Receptor Ionotropic Kainate 3, Rat | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK4_RAT | Q01812 | Glutamate Receptor Ionotropic Kainate 4, Rat | 1600 | 0.74 | Binding ≤ 10μM |
| GRIK5_RAT | Q63273 | Glutamate Receptor Ionotropic Kainate 5, Rat | 1600 | 0.74 | Binding ≤ 10μM |
| GRIA1_MOUSE | P23818 | Glutamate Receptor Ionotropic, AMPA 1, Mouse | 600 | 0.79 | Binding ≤ 10μM |
| GRIA2_RAT | P19491 | Glutamate Receptor Ionotropic, AMPA 2, Rat | 600 | 0.79 | Binding ≤ 10μM |
| GRIA3_RAT | P19492 | Glutamate Receptor Ionotropic, AMPA 3, Rat | 600 | 0.79 | Binding ≤ 10μM |
| GRIA4_RAT | P19493 | Glutamate Receptor Ionotropic, AMPA 4, Rat | 600 | 0.79 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Activation of Ca-permeable Kainate Receptor | |
| Activation of Na-permeable Kainate Receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
