Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.03	9.96	-36.9	1	3	1	31	262.373	5	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	3.03	7.61	-5.04	0	3	0	30	261.365	5	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	5000	0.39	Binding ≤ 10μM
OPRK-3-E	Kappa Opioid Receptor (cluster #3 Of 6), Eukaryotic	Eukaryotes	5000	0.39	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	5000	0.39	Binding ≤ 10μM
SGMR1-1-E	Sigma Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	5000	0.39	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	5000	0.39	Binding ≤ 10μM
OPRD_MOUSE	P32300	Delta Opioid Receptor, Mouse	5000	0.39	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	5000	0.39	Binding ≤ 10μM
OPRK_MOUSE	P33534	Kappa Opioid Receptor, Mouse	5000	0.39	Binding ≤ 10μM
OPRM_MOUSE	P42866	Mu Opioid Receptor, Mouse	5000	0.39	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	5000	0.39	Binding ≤ 10μM
SGMR1_HUMAN	Q99720	Sigma Opioid Receptor, Human	5000	0.39	Binding ≤ 10μM
SGMR1_MOUSE	O55242	Sigma Opioid Receptor, Mouse	5000	0.39	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRM_HUMAN) Mus musculus (OPRD_MOUSE)
G-protein activation	Mus musculus (OPRM_MOUSE) Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Mus musculus (OPRM_MOUSE) Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Homo sapiens (OPRM_HUMAN) Mus musculus (OPRD_MOUSE)