| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 14th, 2009 | 34 | Yes |
Popular Name: 4-[3-[4-[5-(3,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]phenoxy]-2-oxo-propoxy]benzoic 4-[3-[4-[5-(3,4-dichlorophenyl)-…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.83 | 12.16 | -62.11 | 0 | 8 | -1 | 115 | 498.298 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PA24A-2-E | Cytosolic Phospholipase A2 (cluster #2 Of 3), Eukaryotic | Eukaryotes | 40 | 0.30 | Binding ≤ 10μM |
| PA24B-1-E | Phospholipase A2 Group 1VB (cluster #1 Of 2), Eukaryotic | Eukaryotes | 40 | 0.30 | Binding ≤ 10μM |
| PA24C-1-E | Cytosolic Phospholipase A2 Gamma (cluster #1 Of 2), Eukaryotic | Eukaryotes | 40 | 0.30 | Binding ≤ 10μM |
| PA24D-1-E | Phospholipase A2 Group 1VD (cluster #1 Of 1), Eukaryotic | Eukaryotes | 40 | 0.30 | Binding ≤ 10μM |
| PA2G6-1-E | Calcium-independent Phospholipase A2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 40 | 0.30 | Binding ≤ 10μM |
| Z80156-1-O | HL-60 (Promyeloblast Leukemia Cells) (cluster #1 Of 12), Other | Other | 4700 | 0.22 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PA2G6_HUMAN | O60733 | Calcium-independent Phospholipase A2, Human | 40 | 0.30 | Binding ≤ 1μM |
| PA24A_HUMAN | P47712 | Cytosolic Phospholipase A2, Human | 40 | 0.30 | Binding ≤ 1μM |
| PA24C_HUMAN | Q9UP65 | Cytosolic Phospholipase A2 Gamma, Human | 40 | 0.30 | Binding ≤ 1μM |
| PA24B_HUMAN | P0C869 | Phospholipase A2 Group 1VB, Human | 40 | 0.30 | Binding ≤ 1μM |
| PA24D_HUMAN | Q86XP0 | Phospholipase A2 Group 1VD, Human | 40 | 0.30 | Binding ≤ 1μM |
| PA2G6_HUMAN | O60733 | Calcium-independent Phospholipase A2, Human | 40 | 0.30 | Binding ≤ 10μM |
| PA24A_HUMAN | P47712 | Cytosolic Phospholipase A2, Human | 40 | 0.30 | Binding ≤ 10μM |
| PA24C_HUMAN | Q9UP65 | Cytosolic Phospholipase A2 Gamma, Human | 40 | 0.30 | Binding ≤ 10μM |
| PA24B_HUMAN | P0C869 | Phospholipase A2 Group 1VB, Human | 40 | 0.30 | Binding ≤ 10μM |
| PA24D_HUMAN | Q86XP0 | Phospholipase A2 Group 1VD, Human | 40 | 0.30 | Binding ≤ 10μM |
| Z80156 | Z80156 | HL-60 (Promyeloblast Leukemia Cells) | 4700 | 0.22 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Acyl chain remodeling of CL | |
| Acyl chain remodelling of PC | |
| Acyl chain remodelling of PE | |
| Acyl chain remodelling of PG | |
| Acyl chain remodelling of PI | |
| Acyl chain remodelling of PS | |
| ADP signalling through P2Y purinoceptor 1 | |
| Arachidonic acid metabolism | |
| Hydrolysis of LPC | |
| Hydrolysis of LPE | |
| phospho-PLA2 pathway | |
| Platelet sensitization by LDL | |
| Role of phospholipids in phagocytosis | |
| Synthesis of PA | |
| XBP1(S) activates chaperone genes |
