| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 23rd, 2004 | 13 | Yes |
Popular Name: 6-Chloroquinoxaline-2,3-diol 6-Chloroquinoxaline-2,3-diol
Find On: PubMed — Wikipedia — Google
CAS Number: 6639-79-8
"2,3-Dihydroxy-6-chloroquinoxaline, 97%"
2,3-Dihydroxy-6-chloroquinoxaline
6-chloro-1,2,3,4-tetrahydroquinoxaline-2,3-dione
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.20 | -7.16 | -8.4 | 2 | 4 | 0 | 66 | 196.593 | 0 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Purity | 95% | Fluorochem |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRID1-1-E | Glutamate Receptor Delta-1 Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| NMD3A-5-E | Glutamate [NMDA] Receptor Subunit 3A (cluster #5 Of 6), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| NMD3B-5-E | Glutamate [NMDA] Receptor Subunit 3B (cluster #5 Of 6), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE1-3-E | Glutamate [NMDA] Receptor Subunit Epsilon 1 (cluster #3 Of 5), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE2-3-E | Glutamate [NMDA] Receptor Subunit Epsilon 2 (cluster #3 Of 5), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE3-2-E | Glutamate [NMDA] Receptor Subunit Epsilon 3 (cluster #2 Of 4), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE4-5-E | Glutamate [NMDA] Receptor Subunit Epsilon 4 (cluster #5 Of 6), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| NMDZ1-3-E | Glutamate (NMDA) Receptor Subunit Zeta 1 (cluster #3 Of 6), Eukaryotic | Eukaryotes | 1800 | 0.62 | Binding ≤ 10μM |
| Z104302-4-O | Glutamate NMDA Receptor (cluster #4 Of 7), Other | Other | 8400 | 0.55 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMDZ1_HUMAN | Q05586 | Glutamate (NMDA) Receptor Subunit Zeta 1, Human | 1800 | 0.62 | Binding ≤ 10μM |
| NMDZ1_RAT | P35439 | Glutamate (NMDA) Receptor Subunit Zeta 1, Rat | 1800 | 0.62 | Binding ≤ 10μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 1800 | 0.62 | Binding ≤ 10μM |
| GRID1_HUMAN | Q9ULK0 | Glutamate Receptor Delta-1 Subunit, Human | 1800 | 0.62 | Binding ≤ 10μM |
| NMD3A_HUMAN | Q8TCU5 | Glutamate [NMDA] Receptor Subunit 3A, Human | 1800 | 0.62 | Binding ≤ 10μM |
| NMD3B_HUMAN | O60391 | Glutamate [NMDA] Receptor Subunit 3B, Human | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE1_HUMAN | Q12879 | Glutamate [NMDA] Receptor Subunit Epsilon 1, Human | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE2_HUMAN | Q13224 | Glutamate [NMDA] Receptor Subunit Epsilon 2, Human | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE3_HUMAN | Q14957 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Human | 1800 | 0.62 | Binding ≤ 10μM |
| NMDE4_HUMAN | O15399 | Glutamate [NMDA] Receptor Subunit Epsilon 4, Human | 1800 | 0.62 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| CREB phosphorylation through the activation of CaMKII | |
| EPHB-mediated forward signaling | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Unblocking of NMDA receptor, glutamate binding and activation |
