Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	2.18	5.65	-15.7	1	10	0	113	474.587	7	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	2.64	3.87	-56.91	0	10	-1	116	473.579	7	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
PDE1A-1-E	Phosphodiesterase 1A (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.28	Binding ≤ 10μM
PDE1B-1-E	Phosphodiesterase 1B (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.28	Binding ≤ 10μM
PDE1C-1-E	Phosphodiesterase 1C (cluster #1 Of 1), Eukaryotic	Eukaryotes	300	0.28	Binding ≤ 10μM
PDE5A-1-E	Phosphodiesterase 5A (cluster #1 Of 2), Eukaryotic	Eukaryotes	2	0.37	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
PDE1A_HUMAN	P54750	Phosphodiesterase 1A, Human	300	0.28	Binding ≤ 1μM
PDE1A_BOVIN	P14100	Phosphodiesterase 1A, Bovin	300	0.28	Binding ≤ 1μM
PDE1B_HUMAN	Q01064	Phosphodiesterase 1B, Human	300	0.28	Binding ≤ 1μM
PDE1B_BOVIN	Q01061	Phosphodiesterase 1B, Bovin	300	0.28	Binding ≤ 1μM
PDE1C_HUMAN	Q14123	Phosphodiesterase 1C, Human	300	0.28	Binding ≤ 1μM
PDE5A_HUMAN	O76074	Phosphodiesterase 5A, Human	0.6	0.39	Binding ≤ 1μM
PDE1A_HUMAN	P54750	Phosphodiesterase 1A, Human	300	0.28	Binding ≤ 10μM
PDE1A_BOVIN	P14100	Phosphodiesterase 1A, Bovin	300	0.28	Binding ≤ 10μM
PDE1B_HUMAN	Q01064	Phosphodiesterase 1B, Human	300	0.28	Binding ≤ 10μM
PDE1B_BOVIN	Q01061	Phosphodiesterase 1B, Bovin	300	0.28	Binding ≤ 10μM
PDE1C_HUMAN	Q14123	Phosphodiesterase 1C, Human	300	0.28	Binding ≤ 10μM
PDE5A_HUMAN	O76074	Phosphodiesterase 5A, Human	0.6	0.39	Binding ≤ 10μM

Description	Species
Cam-PDE 1 activation	Bos taurus (PDE1A_BOVIN) Homo sapiens (PDE1A_HUMAN)
cGMP effects	Homo sapiens (PDE5A_HUMAN) Bos taurus (PDE1A_BOVIN)
G alpha (s) signalling events	Homo sapiens (PDE1A_HUMAN) Bos taurus (PDE1A_BOVIN)