Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	-0.94	7.9	-66.5	6	10	0	167	538.645	11	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	-0.94	7.7	-70.1	5	10	-1	165	537.637	11	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	87	0.25	Binding ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	1500	0.21	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD_PIG	P79291	Delta Opioid Receptor, Pig	0.1	0.36	Binding ≤ 1μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	0.1	0.36	Binding ≤ 1μM
OPRM_MOUSE	P42866	Mu Opioid Receptor, Mouse	86.8	0.25	Binding ≤ 1μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	86.8	0.25	Binding ≤ 1μM
OPRD_PIG	P79291	Delta Opioid Receptor, Pig	0.1	0.36	Binding ≤ 10μM
OPRD_RAT	P33533	Delta Opioid Receptor, Rat	0.1	0.36	Binding ≤ 10μM
OPRM_MOUSE	P42866	Mu Opioid Receptor, Mouse	1051	0.21	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	1051	0.21	Binding ≤ 10μM
OPRM_CAVPO	P97266	Mu Opioid Receptor, Guinea Pig	1500	0.21	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Sus scrofa (OPRD_PIG) Rattus norvegicus (OPRD_RAT) Mus musculus (OPRM_MOUSE)
G-protein activation	Mus musculus (OPRM_MOUSE) Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Mus musculus (OPRM_MOUSE) Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Mus musculus (OPRM_MOUSE) Sus scrofa (OPRD_PIG) Rattus norvegicus (OPRD_RAT)