In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
July 23rd, 2004 | 15 | Yes |
Popular Name: DNC007640 DNC007640
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.04 | 1.5 | -6 | 0 | 3 | 0 | 34 | 265.11 | 1 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ELNE-3-E | Neutrophil Elastase (cluster #3 Of 3), Eukaryotic | Eukaryotes | 45 | 0.69 | Binding ≤ 10μM |
KLKB1-1-E | Plasma Kallikrein (cluster #1 Of 3), Eukaryotic | Eukaryotes | 6200 | 0.49 | Binding ≤ 10μM |
THRB-5-E | Prothrombin (cluster #5 Of 8), Eukaryotic | Eukaryotes | 4700 | 0.50 | Binding ≤ 10μM |
UROK-1-E | Urokinase-type Plasminogen Activator (cluster #1 Of 4), Eukaryotic | Eukaryotes | 1700 | 0.54 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ELNE_HUMAN | P08246 | Leukocyte Elastase, Human | 45 | 0.69 | Binding ≤ 1μM |
ELNE_HUMAN | P08246 | Leukocyte Elastase, Human | 45 | 0.69 | Binding ≤ 10μM |
KLKB1_HUMAN | P03952 | Plasma Kallikrein, Human | 6200 | 0.49 | Binding ≤ 10μM |
THRB_HUMAN | P00734 | Thrombin, Human | 4700 | 0.50 | Binding ≤ 10μM |
UROK_HUMAN | P00749 | Urokinase-type Plasminogen Activator, Human | 1700 | 0.54 | Binding ≤ 10μM |
Description | Species |
---|---|
Activation of Matrix Metalloproteinases | |
Cell surface interactions at the vascular wall | |
Collagen degradation | |
Common Pathway | |
Degradation of the extracellular matrix | |
Dissolution of Fibrin Clot | |
G alpha (q) signalling events | |
Gamma-carboxylation of protein precursors | |
Intrinsic Pathway | |
Peptide ligand-binding receptors | |
Platelet Aggregation (Plug Formation) | |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
Thrombin signalling through proteinase activated receptors (PARs) | |
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu |
No pre-computed analogs available. Try a structural similarity search.