| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 27th, 2005 | 23 | No |
Popular Name: Triciribine Triciribine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 35943-35-2 , [35943-35-2]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -1.07 | -3.05 | -19.05 | 5 | 10 | 0 | 144 | 320.309 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Target | Akt | Selleck Chemicals |
| Reactome Database Links | REACT_147895 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q72547-1-V | Human Immunodeficiency Virus Type 1 Reverse Transcriptase (cluster #1 Of 6), Viral | Viruses | 40 | 0.45 | Binding ≤ 10μM |
| Z50530-1-O | Human Herpesvirus 5 (cluster #1 Of 5), Other | Other | 2500 | 0.34 | Functional ≤ 10μM |
| Z50607-1-O | Human Immunodeficiency Virus 1 (cluster #1 Of 10), Other | Other | 90 | 0.43 | Functional ≤ 10μM |
| Z50609-2-O | Simian Immunodeficiency Virus (cluster #2 Of 2), Other | Other | 60 | 0.44 | Functional ≤ 10μM |
| Z50658-1-O | Human Immunodeficiency Virus 2 (cluster #1 Of 4), Other | Other | 6 | 0.50 | Functional ≤ 10μM |
| Z80169-1-O | Huh-7 (Hepatocellular Carcinoma) (cluster #1 Of 1), Other | Other | 2000 | 0.35 | Functional ≤ 10μM |
| Z80193-2-O | L1210 (Lymphocytic Leukemia Cells) (cluster #2 Of 12), Other | Other | 35 | 0.45 | Functional ≤ 10μM |
| Z80954-1-O | HFF (Foreskin Fibroblasts) (cluster #1 Of 4), Other | Other | 2500 | 0.34 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q72547_9HIV1 | Q72547 | Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 | 20 | 0.47 | Binding ≤ 1μM |
| Q72547_9HIV1 | Q72547 | Human Immunodeficiency Virus Type 1 Reverse Transcriptase, 9hiv1 | 20 | 0.47 | Binding ≤ 10μM |
| Z80954 | Z80954 | HFF (Foreskin Fibroblasts) | 2500 | 0.34 | Functional ≤ 10μM |
| Z80169 | Z80169 | Huh-7 (Hepatocellular Carcinoma) | 2000 | 0.35 | Functional ≤ 10μM |
| Z50530 | Z50530 | Human Herpesvirus 5 | 2500 | 0.34 | Functional ≤ 10μM |
| Z50607 | Z50607 | Human Immunodeficiency Virus 1 | 10 | 0.49 | Functional ≤ 10μM |
| Z50658 | Z50658 | Human Immunodeficiency Virus 2 | 20 | 0.47 | Functional ≤ 10μM |
| Z80193 | Z80193 | L1210 (Lymphocytic Leukemia Cells) | 35 | 0.45 | Functional ≤ 10μM |
| Z50609 | Z50609 | Simian Immunodeficiency Virus | 40 | 0.45 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Constitutive PI3K/AKT Signaling in Cancer |
