| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 4th, 2005 | 15 | Yes |
Popular Name: DNC014584 DNC014584
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.26 | 4.66 | -123.33 | 0 | 5 | -2 | 89 | 212.201 | 2 | ↓ |
| Lo Low (pH 4.5-6) | 0.26 | 2.76 | -40.74 | 1 | 5 | -1 | 87 | 213.209 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PP1A-1-E | Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 600 | 0.58 | Binding ≤ 10μM |
| PP1G-1-E | Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 600 | 0.58 | Binding ≤ 10μM |
| Q8AWE3-1-E | Serine-threonine Protein Phosphatase 2A Regulatory Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 50 | 0.68 | Binding ≤ 10μM |
| Z50425-1-O | Plasmodium Falciparum (cluster #1 Of 22), Other | Other | 3162 | 0.51 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q8AWE3_CHICK | Q8AWE3 | Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick | 50 | 0.68 | Binding ≤ 1μM |
| PP1A_HUMAN | P62136 | Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human | 600 | 0.58 | Binding ≤ 1μM |
| PP1G_HUMAN | P36873 | Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human | 600 | 0.58 | Binding ≤ 1μM |
| Q8AWE3_CHICK | Q8AWE3 | Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick | 50 | 0.68 | Binding ≤ 10μM |
| PP1A_HUMAN | P62136 | Serine/threonine Protein Phosphatase PP1-alpha Catalytic Subunit, Human | 600 | 0.58 | Binding ≤ 10μM |
| PP1G_HUMAN | P36873 | Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human | 600 | 0.58 | Binding ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 1258.92541 | 0.55 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| DARPP-32 events | |
| Downregulation of TGF-beta receptor signaling | |
| Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | |
| Mitotic Prometaphase | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids |
