| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 20th, 2005 | 34 | Yes |
Popular Name: BMS-214662 BMS-214662
Find On: PubMed — Wikipedia — Google
CAS Numbers: 195981-08-9 , 195987-41-8 , 761389-11-1
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.66 | 12.08 | -52.1 | 2 | 7 | 1 | 94 | 490.634 | 6 | ↓ |
| Ref Reference (pH 7) | 3.66 | 12.06 | -52.02 | 2 | 7 | 1 | 94 | 490.634 | 6 | ↓ |
| Mid Mid (pH 6-8) | 3.66 | 11.8 | -15.02 | 1 | 7 | 0 | 93 | 489.626 | 6 | ↓ |
| Mid Mid (pH 6-8) | 3.66 | 11.56 | -16.22 | 1 | 7 | 0 | 93 | 489.626 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FNTA-1-E | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2300 | 0.23 | Binding ≤ 10μM |
| FNTB-1-E | Protein Farnesyltransferase Beta Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 1 | 0.37 | Binding ≤ 10μM |
| PGTB1-1-E | Geranylgeranyl Transferase Type I Beta Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2300 | 0.23 | Binding ≤ 10μM |
| Q5EI73-1-E | Protein Farnesyltransferase Alpha Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.33 | Binding ≤ 10μM |
| Q5EI74-1-E | Protein Farnesyltransferase Beta Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.33 | Binding ≤ 10μM |
| Z80951-1-O | NIH3T3 (Fibroblasts) (cluster #1 Of 4), Other | Other | 25 | 0.31 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Q5EI73_PLAFA | Q5EI73 | Protein Farnesyltransferase Alpha Subunit, Plafa | 8 | 0.33 | Binding ≤ 1μM |
| Q5EI74_PLAFA | Q5EI74 | Protein Farnesyltransferase Beta Subunit, Plafa | 8 | 0.33 | Binding ≤ 1μM |
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 0.7 | 0.38 | Binding ≤ 1μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 0.7 | 0.38 | Binding ≤ 1μM |
| PGTB1_HUMAN | P53609 | Geranylgeranyl Transferase Type I Beta Subunit, Human | 1300 | 0.24 | Binding ≤ 10μM |
| Q5EI73_PLAFA | Q5EI73 | Protein Farnesyltransferase Alpha Subunit, Plafa | 8 | 0.33 | Binding ≤ 10μM |
| Q5EI74_PLAFA | Q5EI74 | Protein Farnesyltransferase Beta Subunit, Plafa | 8 | 0.33 | Binding ≤ 10μM |
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 0.7 | 0.38 | Binding ≤ 10μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 0.7 | 0.38 | Binding ≤ 10μM |
| Z80951 | Z80951 | NIH3T3 (Fibroblasts) | 25 | 0.31 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Apoptotic cleavage of cellular proteins | |
| Inactivation, recovery and regulation of the phototransduction cascade |
