| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| December 21st, 2005 | 27 | Yes |
Popular Name: 2-Arachidonoylglycerol 2-Arachidonoylglycerol
Find On: PubMed — Wikipedia — Google
CAS Numbers: 53847-30-6 , 924894-97-3 , [53847-30-6]
2-(5Z,8Z,11Z,14Z)-eicosatetraenoylglycerol
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol-d5
2-AG; 2-Arachidonoyl-sn-glycerol; 2-Arachidonoylglycerol; 53847-30-6; C13856
2-AG; 2-arachidonoylglycerol; CPD-12600
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.45 | 11.89 | -8.62 | 2 | 4 | 0 | 67 | 378.553 | 18 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| UniProt Database Links | ABD12_BOVIN; ABD12_CHICK; ABD12_HUMAN; ABD12_MACFA; ABD12_MOUSE; ABD12_RAT; ABHD6_BOVIN; ABHD6_HUMAN; ABHD6_MOUSE; ABHD6_RAT; CNR2_HUMAN; CNR2_MOUSE; CNR2_RAT; DGLA_HUMAN; DGLA_MOUSE; DGLA_RAT; DGLB_HUMAN; DGLB_MOUSE; DGLB_RAT; MGLL_HUMAN; MGLL_MOUSE; MGL | ChEBI |
| Reactome Database Links | REACT_15538; REACT_18279; REACT_19135; REACT_19155; REACT_22239; REACT_22289 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CNR1-2-E | Cannabinoid CB1 Receptor (cluster #2 Of 5), Eukaryotic | Eukaryotes | 480 | 0.33 | Binding ≤ 10μM |
| CNR2-2-E | Cannabinoid CB2 Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 100 | 0.36 | Binding ≤ 10μM |
| FAAH1-4-E | Anandamide Amidohydrolase (cluster #4 Of 7), Eukaryotic | Eukaryotes | 5000 | 0.27 | Binding ≤ 10μM |
| CNR1-1-E | Cannabinoid CB1 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 23 | 0.40 | Functional ≤ 10μM |
| CNR2-2-E | Cannabinoid CB2 Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 17 | 0.40 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CNR1_HUMAN | P21554 | Cannabinoid CB1 Receptor, Human | 480 | 0.33 | Binding ≤ 1μM |
| CNR1_RAT | P20272 | Cannabinoid CB1 Receptor, Rat | 100 | 0.36 | Binding ≤ 1μM |
| CNR2_RAT | Q9QZN9 | Cannabinoid CB2 Receptor, Rat | 100 | 0.36 | Binding ≤ 1μM |
| FAAH1_HUMAN | O00519 | Anandamide Amidohydrolase, Human | 5000 | 0.27 | Binding ≤ 10μM |
| CNR1_HUMAN | P21554 | Cannabinoid CB1 Receptor, Human | 480 | 0.33 | Binding ≤ 10μM |
| CNR1_RAT | P20272 | Cannabinoid CB1 Receptor, Rat | 100 | 0.36 | Binding ≤ 10μM |
| CNR2_RAT | Q9QZN9 | Cannabinoid CB2 Receptor, Rat | 100 | 0.36 | Binding ≤ 10μM |
| CNR2_HUMAN | P34972 | Cannabinoid CB2 Receptor, Human | 1300 | 0.31 | Binding ≤ 10μM |
| CNR1_HUMAN | P21554 | Cannabinoid CB1 Receptor, Human | 23 | 0.40 | Functional ≤ 10μM |
| CNR2_HUMAN | P34972 | Cannabinoid CB2 Receptor, Human | 17 | 0.40 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Arachidonate production from DAG |
|
| Class A/1 (Rhodopsin-like receptors) | |
| G alpha (i) signalling events |
| Description | Species |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | |
| G alpha (i) signalling events |
