| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 17th, 2010 | 34 | Yes |
Popular Name: puromycin hydrochloride puromycin hydrochloride
Find On: PubMed — Wikipedia — Google
CAS Numbers: 53-79-2 , 58-58-2 , 58-58-2, 53-79-2 [puromyc , 58-58-2, 53-79-2 [puromycin] , [58-58-2]
"Puromycin dihydrochloride hydrate, 98%"
3'-{[(2S)-2-ammonio-3-(4-methoxyphenyl)propanoyl]amino}-3'-deoxy-N,N-dimethyladenosine; puromycin
3123L; CL-13900; GNF-Pf-2016; P-638; TCMDC-123493; CL-16536
58-58-2; C11618; Puromycin dihydrochloride
58-58-2; D05655; Puromycin hydrochloride (USAN)
CHEBI:45182; CHEBI:14970; CHEBI:26402; CHEBI:8641
puromicina; puromycin; puromycine; puromycinum
Puromycin dihydrochloride hydrate, 99%
Puromycin Dihydrochloride [58-58-2]
Puromycin dihydrochloride.Cell cultured tested
PUROMYCIN DIHYDROCHLORIDE; [58-58-2]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Hi High (pH 8-9.5) | 2.58 | 7.12 | -5.27 | 0 | 2 | 0 | 18 | 174.247 | 1 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.01e+00 g/l | DrugBank-experimental |
| Mp [°C] | 168 - 178 | Acros Organics |
| Purity | >98% | Fluorochem |
| UniProt Database Links | ACRZ_ECOLI; CLPE_LACLM; EFP_ECOLI; ERAP1_HUMAN; ERAP1_MOUSE; ERAP1_RAT; FA32A_HUMAN; HTRA_BACSU; HTRA_LACHE; HTRA_LACLA; HTRA_LACLM; HTRB_BACSU; IGSF5_RAT; LON_BRUA2; MDFA_ECOLI; MDTN_ECO57; MDTN_ECOL6; MDTN_ECOLI; MDTN_SHIFL; MDTO_ECO57; MDTO_ECOL6; MDTO | ChEBI |
| biological_use | Antibiotic | IBScreen Bioactives ZereneX Building Blocks |
| Therapy | antineoplastic, antiprotozoal | SMDC MicroSource |
| biological_use | Cytostatic | IBScreen Bioactives |
| PUBCHEM_PATENT_ID | EP0082088A1; EP0187547A2; EP0187547B1; EP0195906A2; EP0195906B1; EP0206726A2; EP0206726B2; EP0292710A2; EP0292710B1; EP0375724A1; EP0375724B1; EP0384731A2; EP0384731B1; EP0395476A2; EP0409406A2; EP0409406B1; EP0492088B1; EP0526608B1; EP0563134A1; EP056313 | IBM Patent Data |
| Patent Database Links | EP1574499; EP1710256; EP1726650; EP1842909; EP1967189; EP1995309; US2003105066; US2007178585; US2007248537; US2007258948; US2007258962; US2007269430; US2008292585; WO2005075449; WO2005085196; WO2006121518; WO2008117079 | ChEBI |
| H phrase | H302: Harmful if swallowed | Acros Organics |
| biological_source | Isol. from Streptomyces alboniger | ZereneX Building Blocks |
| P phrase | P301+ P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell | Acros Organics |
| mechanism | Protein synthesis inhibitor | ZereneX Building Blocks |
| R phrase | R22: Harmful if swallowed. | Acros Organics |
| Hazard | XN: Harmful | Acros Organics |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z50420-2-O | Trypanosoma Brucei Brucei (cluster #2 Of 7), Other | Other | 37 | 0.31 | Functional ≤ 10μM |
| Z80186-1-O | K562 (Erythroleukemia Cells) (cluster #1 Of 11), Other | Other | 220 | 0.27 | Functional ≤ 10μM |
| Z81020-1-O | HepG2 (Hepatoblastoma Cells) (cluster #1 Of 8), Other | Other | 230 | 0.27 | Functional ≤ 10μM |
| Z80936-1-O | HEK293 (Embryonic Kidney Fibroblasts) (cluster #1 Of 4), Other | Other | 420 | 0.26 | ADME/T ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z81020 | Z81020 | HepG2 (Hepatoblastoma Cells) | 210 | 0.27 | Functional ≤ 10μM |
| Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 220 | 0.27 | Functional ≤ 10μM |
| Z50420 | Z50420 | Trypanosoma Brucei Brucei | 37 | 0.31 | Functional ≤ 10μM |
| Z80936 | Z80936 | HEK293 (Embryonic Kidney Fibroblasts) | 420 | 0.26 | ADME/T ≤ 10μM |
