| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 19th, 2010 | 46 | No |
Popular Name: methyl methyl
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 7.43 | 11.42 | -9.98 | 4 | 11 | 0 | 146 | 640.822 | 18 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| APH1A-1-E | Gamma-secretase Subunit APH-1A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.17 | Binding ≤ 10μM |
| APH1B-1-E | Gamma-secretase Subunit APH-1B (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.17 | Binding ≤ 10μM |
| NICA-1-E | Nicastrin (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.17 | Binding ≤ 10μM |
| PEN2-1-E | Gamma-secretase Subunit PEN-2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.17 | Binding ≤ 10μM |
| PSN1-1-E | Presenilin 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.17 | Binding ≤ 10μM |
| PSN2-1-E | Presenilin 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3000 | 0.17 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| APH1A_HUMAN | Q96BI3 | Gamma-secretase Subunit APH-1A, Human | 10000 | 0.15 | Binding ≤ 10μM |
| APH1B_HUMAN | Q8WW43 | Gamma-secretase Subunit APH-1B, Human | 10000 | 0.15 | Binding ≤ 10μM |
| PEN2_HUMAN | Q9NZ42 | Gamma-secretase Subunit PEN-2, Human | 10000 | 0.15 | Binding ≤ 10μM |
| NICA_HUMAN | Q92542 | Nicastrin, Human | 10000 | 0.15 | Binding ≤ 10μM |
| PSN1_HUMAN | P49768 | Presenilin 1, Human | 10000 | 0.15 | Binding ≤ 10μM |
| PSN2_HUMAN | P49810 | Presenilin 2, Human | 10000 | 0.15 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |
| Degradation of the extracellular matrix | |
| EPH-ephrin mediated repulsion of cells | |
| NOTCH2 Activation and Transmission of Signal to the Nucleus | |
| NRIF signals cell death from the nucleus | |
| Nuclear signaling by ERBB4 | |
| Regulated proteolysis of p75NTR | |
| Signaling by NOTCH3 | |
| Signaling by NOTCH4 |
