| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| January 9th, 2011 | 42 | No |
Popular Name: methyl methyl
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.30 | 4.94 | -136.31 | 9 | 12 | 2 | 201 | 602.758 | 15 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FA10-1-E | Coagulation Factor X (cluster #1 Of 2), Eukaryotic | Eukaryotes | 6100 | 0.17 | Binding ≤ 10μM |
| PLMN-2-E | Plasminogen (cluster #2 Of 2), Eukaryotic | Eukaryotes | 2800 | 0.19 | Binding ≤ 10μM |
| ST14-1-E | Matriptase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6 | 0.27 | Binding ≤ 10μM |
| THRB-1-E | Prothrombin (cluster #1 Of 8), Eukaryotic | Eukaryotes | 600 | 0.21 | Binding ≤ 10μM |
| UROK-2-E | Urokinase-type Plasminogen Activator (cluster #2 Of 4), Eukaryotic | Eukaryotes | 2500 | 0.19 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ST14_HUMAN | Q9Y5Y6 | Matriptase, Human | 6.1 | 0.27 | Binding ≤ 1μM |
| THRB_HUMAN | P00734 | Thrombin, Human | 600 | 0.21 | Binding ≤ 1μM |
| FA10_HUMAN | P00742 | Coagulation Factor X, Human | 6100 | 0.17 | Binding ≤ 10μM |
| ST14_HUMAN | Q9Y5Y6 | Matriptase, Human | 6.1 | 0.27 | Binding ≤ 10μM |
| PLMN_HUMAN | P00747 | Plasminogen, Human | 2800 | 0.19 | Binding ≤ 10μM |
| THRB_HUMAN | P00734 | Thrombin, Human | 600 | 0.21 | Binding ≤ 10μM |
| UROK_HUMAN | P00749 | Urokinase-type Plasminogen Activator, Human | 2500 | 0.19 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Cell surface interactions at the vascular wall | |
| Common Pathway | |
| Degradation of the extracellular matrix | |
| Dissolution of Fibrin Clot | |
| Extrinsic Pathway | |
| G alpha (q) signalling events | |
| Gamma-carboxylation of protein precursors | |
| Intrinsic Pathway | |
| Peptide ligand-binding receptors | |
| Platelet Aggregation (Plug Formation) | |
| Platelet degranulation | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l | |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
| Signaling by PDGF | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulu |
No pre-computed analogs available. Try a structural similarity search.
