| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 4th, 2005 | 15 | Yes |
Popular Name: Apraclonidine Apraclonidine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 66711-21-5 , 73218-79-8 , [66711-21-5] , [73218-79-8]
1,4-Benzenediamine, 2,6-dichloro-N'-(4,5-dihydro-1H-imidazol-2-yl)-
2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
2,6-dichloro-N(1)-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine hydrochloride
2-(4-amino-2,6-dichloro)phenyliminoimidazolidine
2-(4-Amino-2,6-dichloroanilino)-2-imidazoline hydrochloride
4-Aminoclonidine; Apraclonidine
66711-21-5; Apraclonidine (INN); D07461; Iopidine (TN)
66711-21-5; Apraclonidine; C07668
73218-79-8; Apraclonidine hydrochloride (JAN/USP); D01008; Iopidine (TN)
Apraclonidina [INN-Spanish];Apraclonidinum [INN-Latin]
apraclonidina; apraclonidine; apraclonidinum
INN); Apraclonidine Hydrochloride (FDA
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.64 | 4.03 | -24.39 | 5 | 4 | 1 | 64 | 246.121 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 4.09e-01 g/l | DrugBank-approved |
| Purity | 95% | Fluorochem |
| Purity | 98.5% | APIChem |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ADA1A-2-E | Alpha-1a Adrenergic Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 180 | 0.63 | Binding ≤ 10μM |
| ADA1B-4-E | Alpha-1b Adrenergic Receptor (cluster #4 Of 4), Eukaryotic | Eukaryotes | 180 | 0.63 | Binding ≤ 10μM |
| ADA1D-2-E | Alpha-1d Adrenergic Receptor (cluster #2 Of 3), Eukaryotic | Eukaryotes | 180 | 0.63 | Binding ≤ 10μM |
| ADA2A-2-E | Alpha-2a Adrenergic Receptor (cluster #2 Of 4), Eukaryotic | Eukaryotes | 4 | 0.78 | Binding ≤ 10μM |
| ADA2B-2-E | Alpha-2b Adrenergic Receptor (cluster #2 Of 4), Eukaryotic | Eukaryotes | 5 | 0.77 | Binding ≤ 10μM |
| ADA2C-2-E | Alpha-2c Adrenergic Receptor (cluster #2 Of 4), Eukaryotic | Eukaryotes | 4 | 0.78 | Binding ≤ 10μM |
| ADA1A-2-E | Alpha-1a Adrenergic Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 180 | 0.63 | Functional ≤ 10μM |
| ADA1B-1-E | Alpha-1b Adrenergic Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 180 | 0.63 | Functional ≤ 10μM |
| ADA1D-4-E | Alpha-1d Adrenergic Receptor (cluster #4 Of 4), Eukaryotic | Eukaryotes | 180 | 0.63 | Functional ≤ 10μM |
| ADA2A-1-E | Alpha-2a Adrenergic Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2 | 0.81 | Functional ≤ 10μM |
| ADA2B-1-E | Alpha-2b Adrenergic Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2 | 0.81 | Functional ≤ 10μM |
| ADA2C-1-E | Alpha-2c Adrenergic Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2 | 0.81 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ADA1A_HUMAN | P35348 | Alpha-1a Adrenergic Receptor, Human | 180 | 0.63 | Binding ≤ 1μM |
| ADA1B_HUMAN | P35368 | Alpha-1b Adrenergic Receptor, Human | 180 | 0.63 | Binding ≤ 1μM |
| ADA1D_HUMAN | P25100 | Alpha-1d Adrenergic Receptor, Human | 180 | 0.63 | Binding ≤ 1μM |
| ADA2A_HUMAN | P08913 | Alpha-2a Adrenergic Receptor, Human | 2.9 | 0.80 | Binding ≤ 1μM |
| ADA2B_RAT | P19328 | Alpha-2b Adrenergic Receptor, Rat | 4.8 | 0.78 | Binding ≤ 1μM |
| ADA2B_HUMAN | P18089 | Alpha-2b Adrenergic Receptor, Human | 4 | 0.78 | Binding ≤ 1μM |
| ADA2C_HUMAN | P18825 | Alpha-2c Adrenergic Receptor, Human | 30 | 0.70 | Binding ≤ 1μM |
| ADA1A_HUMAN | P35348 | Alpha-1a Adrenergic Receptor, Human | 180 | 0.63 | Binding ≤ 10μM |
| ADA1B_HUMAN | P35368 | Alpha-1b Adrenergic Receptor, Human | 180 | 0.63 | Binding ≤ 10μM |
| ADA1D_HUMAN | P25100 | Alpha-1d Adrenergic Receptor, Human | 180 | 0.63 | Binding ≤ 10μM |
| ADA2A_HUMAN | P08913 | Alpha-2a Adrenergic Receptor, Human | 2.9 | 0.80 | Binding ≤ 10μM |
| ADA2B_HUMAN | P18089 | Alpha-2b Adrenergic Receptor, Human | 4 | 0.78 | Binding ≤ 10μM |
| ADA2B_RAT | P19328 | Alpha-2b Adrenergic Receptor, Rat | 4.8 | 0.78 | Binding ≤ 10μM |
| ADA2C_HUMAN | P18825 | Alpha-2c Adrenergic Receptor, Human | 30 | 0.70 | Binding ≤ 10μM |
| ADA1A_HUMAN | P35348 | Alpha-1a Adrenergic Receptor, Human | 180 | 0.63 | Functional ≤ 10μM |
| ADA1B_HUMAN | P35368 | Alpha-1b Adrenergic Receptor, Human | 180 | 0.63 | Functional ≤ 10μM |
| ADA1D_HUMAN | P25100 | Alpha-1d Adrenergic Receptor, Human | 180 | 0.63 | Functional ≤ 10μM |
| ADA2A_HUMAN | P08913 | Alpha-2a Adrenergic Receptor, Human | 1.9 | 0.81 | Functional ≤ 10μM |
| ADA2B_HUMAN | P18089 | Alpha-2b Adrenergic Receptor, Human | 1.9 | 0.81 | Functional ≤ 10μM |
| ADA2C_HUMAN | P18825 | Alpha-2c Adrenergic Receptor, Human | 1.9 | 0.81 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Adrenaline signalling through Alpha-2 adrenergic receptor | |
| Adrenaline,noradrenaline inhibits insulin secretion | |
| Adrenoceptors | |
| G alpha (12/13) signalling events | |
| G alpha (i) signalling events | |
| G alpha (q) signalling events | |
| G alpha (z) signalling events |
