In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
August 18th, 2011 | 23 | Yes |
Popular Name: 4-amino-2,7-dimethyl-N-(6-methyl-3-pyridyl)quinazoline-8-carboxamide 4-amino-2,7-dimethyl-N-(6-methyl…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 1.46 | 4.83 | -16.61 | 3 | 6 | 0 | 94 | 307.357 | 2 | ↓ |
Lo Low (pH 4.5-6) | 1.46 | 5.17 | -32.6 | 4 | 6 | 1 | 95 | 308.365 | 2 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
MTOR-2-E | Serine/threonine-protein Kinase MTOR (cluster #2 Of 3), Eukaryotic | Eukaryotes | 3250 | 0.33 | Binding ≤ 10μM |
PK3CA-2-E | PI3-kinase P110-alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 4550 | 0.33 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
MTOR_HUMAN | P42345 | FK506 Binding Protein 12, Human | 3250 | 0.33 | Binding ≤ 10μM |
PK3CA_HUMAN | P42336 | PI3-kinase P110-alpha Subunit, Human | 4550 | 0.33 | Binding ≤ 10μM |
Description | Species |
---|---|
CD28 dependent PI3K/Akt signaling | |
Constitutive PI3K/AKT Signaling in Cancer | |
Costimulation by the CD28 family | |
DAP12 signaling | |
Downstream signal transduction | |
Downstream TCR signaling | |
G alpha (12/13) signalling events | |
G alpha (q) signalling events | |
GAB1 signalosome | |
GPVI-mediated activation cascade | |
HSF1-dependent transactivation | |
Interleukin receptor SHC signaling | |
Interleukin-3, 5 and GM-CSF signaling | |
mTOR signalling | |
Nephrin interactions | |
PI-3K cascade | |
PI3K Cascade | |
PI3K events in ERBB2 signaling | |
PI3K events in ERBB4 signaling | |
PI3K/AKT activation | |
PIP3 activates AKT signaling | |
Regulation of signaling by CBL | |
Release of eIF4E | |
Role of LAT2/NTAL/LAB on calcium mobilization | |
Role of phospholipids in phagocytosis | |
S6K1-mediated signalling | |
Signaling by constitutively active EGFR | |
Signaling by FGFR mutants | |
Signaling by FGFR1 fusion mutants | |
Signaling by SCF-KIT | |
Synthesis of PIPs at the plasma membrane | |
Tie2 Signaling | |
VEGFA-VEGFR2 Pathway | |
VEGFR2 mediated vascular permeability |
No pre-computed analogs available. Try a structural similarity search.