UCSF

3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Human (370 Compounds)

Swissprot:
3BHS2_HUMAN
Stitch:
3BHS2_HUMAN
UniProt:
P26439
ChEMBL:
CHEMBL3670
Reactome:
REACT_11059
REACT_11036
REACT_11047
PDB:
HSD3B2

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 370 5 1 1
Binding ≤ 1μM 303 5 1 1

Reactome Network (3)

Reactome ID Description Species
REACT_11059 Androgen biosynthesis Homo sapiens
REACT_11036 Glucocorticoid biosynthesis Homo sapiens
REACT_11047 Mineralocorticoid biosynthesis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
3BHS1_HUMAN P14060 CHEMBL1958 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type I, Human 369
S5A1_HUMAN P18405 CHEMBL1787 Steroid 5-alpha-reductase 1, Human 359
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 369

Glucocorticoid biosynthesis

Uniprot Swissprot Chembl Description Number Shared
3BHS1_HUMAN P14060 CHEMBL1958 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type I, Human 369
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 1

Mineralocorticoid biosynthesis

Uniprot Swissprot Chembl Description Number Shared
3BHS1_HUMAN P14060 CHEMBL1958 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type I, Human 369
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
3BHS2_RAT P22072 CHEMBL4821 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Rat 13 1 1 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
3BHS1_HUMAN P14060 CHEMBL1958 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type I, Human 387 5 1 1
3BHS7_HUMAN Q9H2F3 CHEMBL3600 3-beta-hydroxysteroid Dehydrogenase Type VII, Human 116 3 1 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
3BHS1_HUMAN P14060 CHEMBL1958 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type I, Human 369
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 369
S5A1_HUMAN P18405 CHEMBL1787 Steroid 5-alpha-reductase 1, Human 359
3BHS7_HUMAN Q9H2F3 CHEMBL3600 3-beta-hydroxysteroid Dehydrogenase Type VII, Human 116
S5A1_RAT P24008 CHEMBL3422 Steroid 5-alpha-reductase 1, Rat 20
S5A2_RAT P31214 CHEMBL5099 Steroid 5-alpha-reductase 2, Rat 20
3BHS2_RAT P22072 CHEMBL4821 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Rat 12
3BHS5_RAT P27364 CHEMBL4490 3-beta-hydroxysteroid Dehydrogenase Type III, Rat 12
DHI1_HUMAN P28845 CHEMBL4235 11-beta-hydroxysteroid Dehydrogenase 1, Human 1
DHI1_MOUSE P50172 CHEMBL3910 11-beta-hydroxysteroid Dehydrogenase 1, Mouse 1

Most Common Rings