UCSF

Serine/threonine-protein Kinase NEK6, Human (4 Compounds)

Swissprot:
NEK6_HUMAN
Stitch:
NEK6_HUMAN
UniProt:
Q9HC98
ChEMBL:
CHEMBL4309
Reactome:
REACT_160122
REACT_163931
PDB:
NEK6

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 4 1 0 1
Binding ≤ 1μM 2 0 0 0

Reactome Network (2)

Reactome ID Description Species
REACT_160122 Activation of NIMA Kinases NEK9, NEK6, NEK7 Homo sapiens
REACT_163931 Nuclear Pore Complex (NPC) Disassembly Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
NEK7_HUMAN Q8TDX7 CHEMBL4849 Serine/threonine-protein Kinase NEK7, Human 1
NEK9_HUMAN Q8TD19 CHEMBL5257 Serine/threonine-protein Kinase NEK9, Human 1
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 3

Nuclear Pore Complex (NPC) Disassembly

Uniprot Swissprot Chembl Description Number Shared
NEK7_HUMAN Q8TDX7 CHEMBL4849 Serine/threonine-protein Kinase NEK7, Human 1
NEK9_HUMAN Q8TD19 CHEMBL5257 Serine/threonine-protein Kinase NEK9, Human 1
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NEK1_HUMAN Q96PY6 CHEMBL5855 Serine/threonine-protein Kinase Nek1, Human 4 2 2 2
NEK2_HUMAN P51955 CHEMBL3835 Serine/threonine-protein Kinase NEK2, Human 58 8 4 5
NEK5_HUMAN Q6P3R8 CHEMBL5044 Serine/threonine-protein Kinase Nek5, Human 5 4 1 2
NEK7_HUMAN Q8TDX7 CHEMBL4849 Serine/threonine-protein Kinase NEK7, Human 5 5 2 3
NEK9_HUMAN Q8TD19 CHEMBL5257 Serine/threonine-protein Kinase NEK9, Human 2 2 1 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 4
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 3
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 3
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 2
PLK2_HUMAN Q9NYY3 CHEMBL5938 Serine/threonine-protein Kinase PLK2, Human 2
AAK1_HUMAN Q2M2I8 CHEMBL3830 Adaptor-associated Kinase, Human 1
AAPK1_HUMAN Q13131 CHEMBL4045 AMP-activated Protein Kinase, Alpha-1 Subunit, Human 1
AAPK2_HUMAN P54646 CHEMBL2116 AMP-activated Protein Kinase, Alpha-2 Subunit, Human 1
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 1
ANKK1_HUMAN Q8NFD2 CHEMBL5547 Ankyrin Repeat And Protein Kinase Domain-containing Protein 1, Human 1
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 1
AURKC_HUMAN Q9UQB9 CHEMBL3935 Serine/threonine-protein Kinase Aurora-C, Human 1
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 1
BMP2K_HUMAN Q9NSY1 CHEMBL4522 BMP-2-inducible Protein Kinase, Human 1
BMPR2_HUMAN Q13873 CHEMBL5467 Bone Morphogenetic Protein Receptor Type-2, Human 1
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 1
CDK17_HUMAN Q00537 CHEMBL5790 Serine/threonine-protein Kinase PCTAIRE-2, Human 1
CDK7_HUMAN P50613 CHEMBL3055 Cyclin-dependent Kinase 7, Human 1
CHK1_HUMAN O14757 CHEMBL4630 Serine/threonine-protein Kinase Chk1, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 1
CSK21_HUMAN P68400 CHEMBL3629 Casein Kinase II Alpha, Human 1
CSK22_HUMAN P19784 CHEMBL4070 Casein Kinase II Alpha (prime), Human 1
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 1
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 1
DCLK3_HUMAN Q9C098 CHEMBL6123 Serine/threonine-protein Kinase DCLK3, Human 1
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 1
E2AK2_HUMAN P19525 CHEMBL5785 Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human 1
E2AK4_HUMAN Q9P2K8 CHEMBL5358 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 1
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 1
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
FGFR3_HUMAN P22607 CHEMBL2742 Fibroblast Growth Factor Receptor 3, Human 1
FGFR4_HUMAN P22455 CHEMBL3973 Fibroblast Growth Factor Receptor 4, Human 1
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 1
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 1
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 1
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 1
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 1
IKKE_HUMAN Q14164 CHEMBL3529 Inhibitor Of Nuclear Factor Kappa B Kinase Epsilon Subunit, Human 1
ITK_HUMAN Q08881 CHEMBL2959 Tyrosine-protein Kinase ITK/TSK, Human 1
JAK1_HUMAN P23458 CHEMBL2835 Tyrosine-protein Kinase JAK1, Human 1
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
KKCC1_HUMAN Q8N5S9 CHEMBL5256 CaM-kinase Kinase Alpha, Human 1
KPCT_HUMAN Q04759 CHEMBL3920 Protein Kinase C Theta, Human 1
KS6A1_HUMAN Q15418 CHEMBL2553 Ribosomal Protein S6 Kinase Alpha 1, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
KS6A3_HUMAN P51812 CHEMBL2345 Ribosomal Protein S6 Kinase Alpha 3, Human 1
KS6A4_HUMAN O75676 CHEMBL3125 Ribosomal Protein S6 Kinase Alpha 4, Human 1
KS6A5_HUMAN O75582 CHEMBL4237 Ribosomal Protein S6 Kinase Alpha 5, Human 1
KS6A6_HUMAN Q9UK32 CHEMBL4924 Ribosomal Protein S6 Kinase Alpha 6, Human 1
LATS1_HUMAN O95835 CHEMBL6167 Serine/threonine-protein Kinase LATS1, Human 1
LATS2_HUMAN Q9NRM7 CHEMBL5907 Serine/threonine-protein Kinase LATS2, Human 1
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 1
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 1
M3K11_HUMAN Q16584 CHEMBL2708 Mitogen-activated Protein Kinase Kinase Kinase 11, Human 1
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 1
M3K9_HUMAN P80192 CHEMBL2872 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 1
M4K1_HUMAN Q92918 CHEMBL5749 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 1
M4K3_HUMAN Q8IVH8 CHEMBL5432 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 1
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 1
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 1
MARK1_HUMAN Q9P0L2 CHEMBL5940 Serine/threonine-protein Kinase MARK1, Human 1
MARK2_HUMAN Q7KZI7 CHEMBL3831 MAP/microtubule Affinity-regulating Kinase 2, Human 1
MARK3_HUMAN P27448 CHEMBL5600 Serine/threonine-protein Kinase C-TAK1, Human 1
MARK4_HUMAN Q96L34 CHEMBL5754 MAP/microtubule Affinity-regulating Kinase 4, Human 1
MELK_HUMAN Q14680 CHEMBL4578 Maternal Embryonic Leucine Zipper Kinase, Human 1
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 1
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 1
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
MUSK_HUMAN O15146 CHEMBL5684 Muscle, Skeletal Receptor Tyrosine Protein Kinase, Human 1
MYLK2_HUMAN Q9H1R3 CHEMBL2777 Myosin Light Chain Kinase 2, Human 1
MYLK4_HUMAN Q86YV6 CHEMBL5426 Myosin Light Chain Kinase Family Member 4, Human 1
MYLK_CHICK P11799 CHEMBL3062 Myosin Light Chain Kinase, Smooth Muscle, Chick 1
MYLK_HUMAN Q15746 CHEMBL2428 Myosin Light Chain Kinase, Smooth Muscle, Human 1
NEK2_HUMAN P51955 CHEMBL3835 Serine/threonine-protein Kinase NEK2, Human 1
NEK5_HUMAN Q6P3R8 CHEMBL5044 Serine/threonine-protein Kinase Nek5, Human 1
NEK7_HUMAN Q8TDX7 CHEMBL4849 Serine/threonine-protein Kinase NEK7, Human 1
NEK9_HUMAN Q8TD19 CHEMBL5257 Serine/threonine-protein Kinase NEK9, Human 1
NTRK1_HUMAN P04629 CHEMBL2815 Nerve Growth Factor Receptor Trk-A, Human 1
NTRK2_HUMAN Q16620 CHEMBL4898 Neurotrophic Tyrosine Kinase Receptor Type 2, Human 1
NTRK3_HUMAN Q16288 CHEMBL5608 NT-3 Growth Factor Receptor, Human 1
NUAK1_HUMAN O60285 CHEMBL5784 NUAK Family SNF1-like Kinase 1, Human 1
NUAK2_HUMAN Q9H093 CHEMBL5698 NUAK Family SNF1-like Kinase 2, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PHKG1_HUMAN Q16816 CHEMBL4004 Phosphorylase Kinase Gamma Subunit 1, Human 1
PHKG2_HUMAN P15735 CHEMBL2349 Phosphorylase Kinase Gamma Subunit 2, Human 1
PI42B_HUMAN P78356 CHEMBL5667 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta, Human 1
PI51A_HUMAN Q99755 CHEMBL5969 Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha, Human 1
PKN1_HUMAN Q16512 CHEMBL3384 Protein Kinase N1, Human 1
PKN2_HUMAN Q16513 CHEMBL3032 Protein Kinase N2, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
RIOK1_HUMAN Q9BRS2 CHEMBL5975 Serine/threonine-protein Kinase RIO1, Human 1
RIOK3_HUMAN O14730 CHEMBL5659 Serine/threonine-protein Kinase RIO3, Human 1
RIPK1_HUMAN Q13546 CHEMBL5464 Receptor-interacting Serine/threonine-protein Kinase 1, Human 1
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 1
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 1
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 1
SRPK1_HUMAN Q96SB4 CHEMBL4375 Serine/threonine-protein Kinase SRPK1, Human 1
SRPK2_HUMAN P78362 CHEMBL5668 Serine/threonine-protein Kinase SRPK2, Human 1
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 1
ST17B_HUMAN O94768 CHEMBL3980 Serine/threonine-protein Kinase 17B, Human 1
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 1
STK11_HUMAN Q15831 CHEMBL5606 Serine/threonine-protein Kinase 11, Human 1
STK24_HUMAN Q9Y6E0 CHEMBL5082 Serine/threonine-protein Kinase 24, Human 1
STK25_HUMAN O00506 CHEMBL5552 Serine/threonine-protein Kinase 25, Human 1
STK3_HUMAN Q13188 CHEMBL4708 Serine/threonine-protein Kinase MST2, Human 1
STK4_HUMAN Q13043 CHEMBL4598 Serine/threonine-protein Kinase MST1, Human 1
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 1
TLK2_HUMAN Q86UE8 CHEMBL5404 Serine/threonine-protein Kinase Tousled-like 2, Human 1
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 1
TYRO3_HUMAN Q06418 CHEMBL5314 Tyrosine-protein Kinase Receptor TYRO3, Human 1
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 1
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 1